Long-term efficacy and safety of once-daily enoxaparin plus warfarin for the outpatient ambulatory treatment of lower-limb deep vein thrombosis in the.

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Presentation transcript:

Long-term efficacy and safety of once-daily enoxaparin plus warfarin for the outpatient ambulatory treatment of lower-limb deep vein thrombosis in the TROMBOTEK trial Mehmet Kurtoglu, MD, Cuneyt Koksoy, MD, Ekim Hasan, MD, Yigit Akcalı, MD, Ozalp Karabay, MD, Ugur Filizcan, MD Journal of Vascular Surgery Volume 52, Issue 5, Pages 1262-1270 (November 2010) DOI: 10.1016/j.jvs.2010.06.070 Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 1 Study plan according to seven consecutive visits within 18 months. CBC, Complete blood count; CT, computed tomography; INR, international normalized ratio; PT, prothrombin time; VTE, venous thromboembolism. Journal of Vascular Surgery 2010 52, 1262-1270DOI: (10.1016/j.jvs.2010.06.070) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 2 Complete recanalization ratios for iliofemoral (n = 67), external iliac (n = 33), common femoral (n = 61), femoral (n = 51), and popliteal veins (n = 29) specific to 3, 12, and 18 months of follow-up. *P < .001 compared with scores obtained at the previous visit. Journal of Vascular Surgery 2010 52, 1262-1270DOI: (10.1016/j.jvs.2010.06.070) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 3 Evaluation of symptom incidence (%) of patients for pain, edema, and tenderness during the course of the treatment. *P < .05 and **P < .001 compared with incidence at the previous visit. +P < .001 compared with pretreatment incidence. Journal of Vascular Surgery 2010 52, 1262-1270DOI: (10.1016/j.jvs.2010.06.070) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 4 Comparison of pretreatment and posttreatment period in terms of average difference in leg circumference (cm) of normal and diseased leg measured at the calf (below the tibial tuberosity) and at the middle thigh regions. *P < .05, **P < .01, and ***P < .001 compared with scores obtained at the previous visit. +P < .001 compared with pretreatment scores. Journal of Vascular Surgery 2010 52, 1262-1270DOI: (10.1016/j.jvs.2010.06.070) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 5 Percentage of patients with subtherapeutic international normalized ratio (INR) ≤2 or ≥3 with respect to the first 90 days. Journal of Vascular Surgery 2010 52, 1262-1270DOI: (10.1016/j.jvs.2010.06.070) Copyright © 2010 Society for Vascular Surgery Terms and Conditions