Lina Carlén, Kazuko Sakuraba, Mona Ståhle, Fabio Sánchez

Slides:

Advertisements

Similar presentations

Francesca Capon Journal of Investigative Dermatology

Advertisements

BM-40(Osteonectin, SPARC) Is Expressed Both in the Epidermal and in the Dermal Compartment of Adult Human Skin Nicholas Hunzelmann, Martin Hafner, Sabine.

Malene Hvid, Christian Vestergaard, Kaare Kemp, Gitte B

IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with Th2 Cytokines to Enhance HSV-1 Replication Byung Eui.

A New View of Vitiligo: Looking at Normal-Appearing Skin

Expression of Neutrophil Gelatinase-Associated Lipocalin in Skin Epidermis Seong Jun Seo, Ji-Young Ahn, Chang-Kwun Hong, Eun-Young Seo, Kyung-Chae Kye,

IL-36γ (IL-1F9) Is a Biomarker for Psoriasis Skin Lesions

Irwin Freedberg: Physician-Scientist and Mentor

Massive Recruitment of Type I Interferon Producing Plasmacytoid Dendritic Cells in Varicella Skin Lesions Gianni Gerlini, Giulia Mariotti, Beatrice Bianchi,

North, South, or East? Blotting Techniques

HLA-Cw6-Positive and HLA-Cw6-Negative Patients with Psoriasis Vulgaris have Distinct Clinical Features Jóhann E. Guðjónsson, Helgi Valdimarsson Journal.

Gene Array Expression Profiling in Acne Lesions Reveals Marked Upregulation of Genes Involved in Inflammation and Matrix Remodeling Nishit R. Trivedi,

Modeling Atopic Dermatitis with Increasingly Complex Mouse Models

Min Qin, Aslan Pirouz, Myung-Hwa Kim, Stephan R. Krutzik, Hermes J

SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice Sijing Xie, Zhonglan Su, Bin Zhang, Jiuyu Ge, Shiyu Song, Guibo.

Sustained Activation of Fibroblast Transforming Growth Factor-β/Smad Signaling in a Murine Model of Scleroderma Shinsuke Takagawa, Gabriella Lakos, Yasuji.

Anne T. Funding, Claus Johansen, Matthias Gaestel, Bo M

Irwin Freedberg, Odysseus for Our Generation

Numerous Keratinocyte Subtypes Involved in Wound Re-Epithelialization

Differential Expression of Phosphorylated NF-κB/RelA in Normal and Psoriatic Epidermis and Downregulation of NF-κB in Response to Treatment with Etanercept

Min Qin, Aslan Pirouz, Myung-Hwa Kim, Stephan R. Krutzik, Hermes J

Francois le Pelletier, Anne Janin Journal of Investigative Dermatology

Mitogen- and Stress-Activated Protein Kinase 1 Is Activated in Lesional Psoriatic Epidermis and Regulates the Expression of Pro-Inflammatory Cytokines

Alice Pentland Journal of Investigative Dermatology

Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin

Clinical Snippets Journal of Investigative Dermatology

Minutes of the Board of Directors Meeting

Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy Yin Fen Ji, M.D., Li You Chen, M.M.,

Superantigens, Autoantigens, and Pathogenic T Cells in Psoriasis

Journal of Investigative Dermatology

Journal of Investigative Dermatology

Birgitta Meding, Karin Wrangsjö, Bengt Järvholm

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis Julie Bayle,

Involvement of αvβ5 Integrin in the Establishment of Autocrine TGF-β Signaling in Dermal Fibroblasts Derived from Localized Scleroderma Yoshihide Asano,

IFN-α Enhances IL-22 Receptor Expression in Keratinocytes: A Possible Role in the Development of Psoriasis Mikiko Tohyama, Lujun Yang, Yasushi Hanakawa,

Mitogen- and Stress-Activated Protein Kinase 2 and Cyclic AMP Response Element Binding Protein are Activated in Lesional Psoriatic Epidermis Anne T.

Transcriptional Profiling of Psoriasis Using RNA-seq Reveals Previously Unidentified Differentially Expressed Genes Ali Jabbari, Mayte Suárez-Fariñas,

Scleroderma Fibroblasts Demonstrate Enhanced Activation of Akt (Protein Kinase B) In Situ Jae-Bum Jun, Melanie Kuechle, Junki Min, Seung Cheol Shim,

Society for Investigative Dermatology 2010 Meeting Minutes

Multiple Epidermal Connexins are Expressed in Different Keratinocyte Subpopulations Including Connexin 31 Wei-Li Di, Elizabeth L. Rugg, Irene M. Leigh,

Delayed Cutaneous Wound Healing in Mice Lacking Solute Carrier 11a1 (Formerly Nramp1): Correlation with Decreased Expression of Secretory Leukocyte Protease.

Cells of Origin in Skin Cancer

RhoC Promotes Human Melanoma Invasion in a PI3K/Akt-Dependent Pathway

Research Snippets Journal of Investigative Dermatology

Clinical Snippets Journal of Investigative Dermatology

Journal of Investigative Dermatology

Nan-Hyung Kim, Ai-Young Lee Journal of Investigative Dermatology

Research Snippets from the British Journal of Dermatology

CD158K/KIR3DL2 Transcript Detection in Lesional Skin of Patients with Erythroderma Is a Tool for the Diagnosis of Sézary Syndrome Nicolas Ortonne, Sabine.

Retinoic Acid Increases Aquaporin 3 Expression in Normal Human Skin

Hyperthermia Induces Endoplasmic Reticulum-Mediated Apoptosis in Melanoma and Non-Melanoma Skin Cancer Cells Yiqun G. Shellman, William R. Howe, Leslie.

Circulating Tumor Cells and Detection of the Melanoma-Associated Antigen HMW-MAA in the Serum of Melanoma Patients Anja Ulmer, Gerhard Fierlbeck Journal.

Alterations of Glucosylceramide-β-Glucosidase Levels in the Skin of Patients with Psoriasis Vulgaris Francesca Alessandrini, Sabine Pfister, Elisabeth.

Blazej Zbytek, Andrzej T. Slominski

Research Snippets Journal of Investigative Dermatology

Journal of Investigative Dermatology

Irwin Freedberg: The Early Years at Harvard

Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis

IFN-Regulatory Factor 5 Gene Variants Interact with the Class I MHC Locus in the Swedish Psoriasis Population Fabio O. Sánchez, M.V. Prasad Linga Reddy,

A Characteristic Subset of Psoriasis-Associated Genes Is Induced by Oncostatin-M in Reconstituted Epidermis Alix Gazel, Martin Rosdy, Béatrice Bertino,

Quantitative Analysis of Melanocytic Tissue Array Reveals Inverse Correlation between Activator Protein-2α and Protease-Activated Receptor-1 Expression.

Lack of Membrane Expression of Interleukin-2 Receptor α Chain (CD25) in Mycosis Fungoides: Application of Laser Scanning Cytometry for Phenotyping of.

Journal of Investigative Dermatology

Journal of Investigative Dermatology

The Environment and Human Health

Redistribution of LRIG Proteins in Psoriasis

The Requirement for Perp in Postnatal Viability and Epithelial Integrity Reflects an Intrinsic Role in Stratified Epithelia Michelle R. Marques, Rebecca.

Kevan G. Lewis, Martin A. Weinstock

Regulation of IL-13 Receptors in Human Keratinocytes

Innate Immunity Stimulates Permeability Barrier Homeostasis

Presentation transcript:

HLA-C Expression Pattern Is Spatially Different between Psoriasis and Eczema Skin Lesions Lina Carlén, Kazuko Sakuraba, Mona Ståhle, Fabio Sánchez Journal of Investigative Dermatology Volume 127, Issue 2, Pages 342-348 (February 2007) DOI: 10.1038/sj.jid.5700549 Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 HLA-C expression detected by immunohistochemistry with mAb L31. (a) Tonsil, (b) adult colon epithelium, (c) fetal colon epithelium, (d) normal skin, (e) plaque psoriasis, (f) allergic contact eczema (original magnification × 20, Bar=100μM, insets: × 100, Bar=20μm) (g) LCL721.221 cells expressing HLA-Cw3 before lipopolysaccharide stimulation, and after (h) 16, (i) 48, and (j) 96hours post-stimulation (original magnification × 40, Bar=50μm). Journal of Investigative Dermatology 2007 127, 342-348DOI: (10.1038/sj.jid.5700549) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 HLA-C protein expression levels in total protein extracts from psoriasis, eczema and normal skin biopsies. (a) Box plot representation of HLA-C expression according to sample group, measured by densitometry on Western blot analysis. (b) Box plot representation of HLA class I expression, measured by densitometry on Western blot analysis and detected by β2-microglobulin staining. LE=lesional eczema, LG=lesional guttate psoriasis, LP=lesional plaque psoriasis, N=normal, NLE=non-lesional eczema, NLG=non-lesional guttate psoriasis, NLP=non-lesional plaque psoriasis. Journal of Investigative Dermatology 2007 127, 342-348DOI: (10.1038/sj.jid.5700549) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Representative Western blot membrane showing total protein smears and specific HLA-C bands. (a) Ponceau staining of the skin protein extracts after transfer to a membrane. (b) Specific L31 signal. C=Control, LE=lesional eczema, LG=lesional guttate psoriasis, LP=lesional plaque psoriasis, N=normal, NLE=non-lesional eczema, NLG=non-lesional guttate psoriasis. Journal of Investigative Dermatology 2007 127, 342-348DOI: (10.1038/sj.jid.5700549) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions