Uric Acid as a Target of Therapy in CKD

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Presentation transcript:

Uric Acid as a Target of Therapy in CKD Diana I. Jalal, MD, Michel Chonchol, MD, Wei Chen, MD, PhD, Giovanni Targher, MD American Journal of Kidney Diseases Volume 61, Issue 1, Pages 134-146 (January 2013) DOI: 10.1053/j.ajkd.2012.07.021 Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Schematic representation of uric acid homeostasis. Abbreviations: CKD, chronic kidney disease; GFR, glomerular filtration rate. American Journal of Kidney Diseases 2013 61, 134-146DOI: (10.1053/j.ajkd.2012.07.021) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Putative mechanisms by which elevated serum uric acid level may contribute to chronic kidney disease (CKD) development and progression. Abbreviations: GFR, glomerular filtration rate; MCP-1, monocyte chemotactic protein 1; NF-KB, nuclear factor-κB; NO, nitric oxide. American Journal of Kidney Diseases 2013 61, 134-146DOI: (10.1053/j.ajkd.2012.07.021) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions