Modeling Methuselah Cell Volume 154, Issue 1, (July 2013)

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Presentation transcript:

Modeling Methuselah Cell Volume 154, Issue 1, (July 2013) Cell Volume 154, Issue 1, (July 2013) DOI: 10.1016/j.cell.2013.06.029 Copyright © 2013 Terms and Conditions

NF-kB-mediated hypothalamic inflammation leads to systemic aging NF-kB-mediated hypothalamic inflammation leads to systemic aging. Inhibiting inflammation or administration of GnRH promotes longevity. Image courtesy of D. Cai. Cell 2013 154, DOI: (10.1016/j.cell.2013.06.029) Copyright © 2013 Terms and Conditions

(Left) A mouse model of progeria (Left) A mouse model of progeria. (Right) A progeric sibling with a hypomorphic allele of ICMT. Image courtesy of M.O. Bergo. Cell 2013 154, DOI: (10.1016/j.cell.2013.06.029) Copyright © 2013 Terms and Conditions

Chromosomes (blue) have short telomeres (red) in cells expressing a p53 mutant with increased activity. Image courtesy of I. Simeonova and F. Toledo. Cell 2013 154, DOI: (10.1016/j.cell.2013.06.029) Copyright © 2013 Terms and Conditions