Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis

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General Information Osteoarthritis and Cartilage

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Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis J. Hirvasniemi, J. Thevenot, J. Multanen, M. Haapea, A. Heinonen, M.T. Nieminen, S. Saarakkala Osteoarthritis and Cartilage Volume 25, Issue 12, Pages 2039-2046 (December 2017) DOI: 10.1016/j.joca.2017.09.008 Copyright © 2017 The Author(s) Terms and Conditions

Fig. 1 Location of ROIs. Two ROIs (black rectangles with continuous line) were placed in subchondral bone immediately below the cartilage–bone interface in the middle part of the medial and lateral tibial plateaus and two ROIs (black squares with dashed line) immediately below the dense subchondral bone area. The purpose of the white dashed lines is to help place the ROIs in the middle of the tibial spine and outer border. Osteoarthritis and Cartilage 2017 25, 2039-2046DOI: (10.1016/j.joca.2017.09.008) Copyright © 2017 The Author(s) Terms and Conditions

Fig. 2 Statistically significant correlations between (a) HIAngles,Paral in medial subchondral bone and dGEMRIC index of medial tibial cartilage, (b) FDHor,0.51 mm in lateral subchondral bone and dGEMRIC index of lateral tibial cartilage, (c) FDVer,0.68 mm in medial subchondral bone and T2 relaxation time of medial tibial cartilage and (d) FDHor,0.51 mm in lateral subchondral bone and T2 relaxation time of lateral tibial cartilage. Osteoarthritis and Cartilage 2017 25, 2039-2046DOI: (10.1016/j.joca.2017.09.008) Copyright © 2017 The Author(s) Terms and Conditions

Fig. 3 Strength and direction of the correlation (Pearson's or Spearman's) between tibial cartilage composition and bone structure parameters in proximal tibia is color coded according to the grayscale bar. n = 93. *P < 0.05, **P < 0.01, SB = subchondral bone, TB = trabecular bone, ELap = entropy of Laplacian-based image, ELBP = entropy of local binary patterns, HIAngles,mean = mean HI for orientation of local patterns, HIAngles,Perp = HI perpendicularly to the bone trabeculae, HIAngles,Paral = HI along the trabeculae, FDHor = fractal dimension of horizontal structures, FDVer = fractal dimension of vertical structures. Osteoarthritis and Cartilage 2017 25, 2039-2046DOI: (10.1016/j.joca.2017.09.008) Copyright © 2017 The Author(s) Terms and Conditions

Supplementary Fig. 4 Strength and direction of the correlation (Pearson's or Spearman's) between tibial cartilage composition and bone structure parameters in proximal tibia for KL0/KL1 subjects (n = 39) is color coded according to the grayscale bar. *P < 0.05, **P < 0.01, SB = subchondral bone, TB = trabecular bone, ELap = entropy of Laplacian-based image, ELBP = entropy of local binary patterns, HIAngles,mean = mean homogeneity index (HI) for orientation of local patterns, HIAngles,Perp = HI perpendicularly to the bone trabeculae, HIAngles,Paral = HI along the trabeculae, FDHor = fractal dimension of horizontal structures, FDVer = fractal dimension of vertical structures. Osteoarthritis and Cartilage 2017 25, 2039-2046DOI: (10.1016/j.joca.2017.09.008) Copyright © 2017 The Author(s) Terms and Conditions

Supplementary Fig. 5 Strength and direction of the correlation (Pearson's or Spearman's) between tibial cartilage composition and bone structure parameters in proximal tibia for KL2 subjects (n = 54) is color coded according to the grayscale bar. Abbreviations are as per Supplementary Fig. 4. Osteoarthritis and Cartilage 2017 25, 2039-2046DOI: (10.1016/j.joca.2017.09.008) Copyright © 2017 The Author(s) Terms and Conditions