Neural surveillance of skeletal homeostasis

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Presentation transcript:

Neural surveillance of skeletal homeostasis Mone Zaidi  Cell Metabolism  Volume 1, Issue 4, Pages 219-221 (April 2005) DOI: 10.1016/j.cmet.2005.03.006 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Frequency (FM)- and amplitude (AM)-modulated arms for hypothalamic surveillance of skeletal homeostasis Short circuits refer to nonleptinergic, non-NPYergic release of adrenergic neurotransmitters, as well as epinephrine release from the adrenals. In addition, neuropeptide-containing nerves richly innervate bone tissue and skeletal blood vessels; however, their physiological significance in skeletal homeostasis is unclear. Abbreviations: NPY—neuropeptide Y; CGRP—calcitonin gene-related peptide; VIP—vasoactive intestinal peptide; Sub P—substance P; Glu—glutamate; TSH—thyroid stimulating hormone; TSHR—TSH receptor; FSH—follicle stimulating hormone; LH—luteinizing hormone; Adrb2—β2-adrenergic receptor; T3 and T4—thyroid hormones; E2—estradiol. Cell Metabolism 2005 1, 219-221DOI: (10.1016/j.cmet.2005.03.006) Copyright © 2005 Elsevier Inc. Terms and Conditions