Osteoarthritis and Cartilage Biocompatibility and degradation OF celecoxib loaded polyesteramide-microspheres after intra-Articular injection in a post-traumatic rat osteoarthritis model  U. Timur, M. Janssen, J. Berard, T. Welting, L. van Rhijn, M. Gijbels, G. Mihov, J. Thies, P. Emans  Osteoarthritis and Cartilage  Volume 24, (April 2016) DOI: 10.1016/j.joca.2016.01.961 Copyright © 2016 Terms and Conditions

Figure 1. Entrapment of microspheres in the synovium Figure 1. Entrapment of microspheres in the synovium. Haematoxylin & Eosin stained section of an OA knee 3 weeks after injection with celecoxib loaded microspheres (A) Thionin stained sections of OA-induced knees 3 weeks after injections with non-loaded microspheres(B) or celecoxib loaded microspheres (C). Red asterisks in (B) and (C) depict a giant cell. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.961) Copyright © 2016 Terms and Conditions

Figure 2. In vivo degradation of PEA-based microspheres Figure 2. In vivo degradation of PEA-based microspheres. PEA levels in rat knees measured directly after injection. 3 weeks and 12 weeks after intra-articular injections with non-loaded or celecoxib loaded PEA microspheres Data are mean ± SEM. N = 6 *P < 0.05. ** P < 0.005. Because no degradation is to be expected directly post injection, we injected celecoxib loaded microspheres as controls at this time point. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.961) Copyright © 2016 Terms and Conditions