Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

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Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation Sandra Maday, Alison E. Twelvetrees, Armen J. Moughamian, Erika L.F. Holzbaur Neuron Volume 84, Issue 2, Pages 292-309 (October 2014) DOI: 10.1016/j.neuron.2014.10.019 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Molecular Mechanisms of Axonal Transport Microtubule motor proteins kinesin and dynein drive the movement of organelles, vesicles, RNA granules, and proteins along the axon. Kinesins drive anterograde transport outward from the soma, and dynein drives retrograde transport back from distal axon. However, most cargos have both motor types bound simultaneously. Cargo-bound motors are regulated by organelle-specific complements of scaffolding and adaptor proteins. To avoid either distal accumulation or distal depletion of cellular components, anterograde and retrograde axonal transport must be in balance. Neuron 2014 84, 292-309DOI: (10.1016/j.neuron.2014.10.019) Copyright © 2014 Elsevier Inc. Terms and Conditions