Alan N. Houghton, Hiroshi Uchi, Jedd D. Wolchok Cancer Cell

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The role of the immune system in early epithelial carcinogenesis: B-ware the double- edged sword Alan N. Houghton, Hiroshi Uchi, Jedd D. Wolchok Cancer Cell Volume 7, Issue 5, Pages 403-405 (May 2005) DOI: 10.1016/j.ccr.2005.04.026 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Model of antibody-mediated inflammation driving early skin carcinogenesis Naive B cells are activated by skin-derived antigens (HPV16 E6, E7, and/or degraded products of keratinocytes and extracellular matrix?) in the presence of CD4 T cells, and differentiate into memory B cells and plasma cells. Antibodies produced by plasma cells stimulate resident myeloid cells (e.g., macrophages) in the dermis via activating Fc receptors to secrete VEGF, MMPs, and other inflammatory mediators, followed by further recruitment of innate immune cells. Chronic inflammation mediated by interaction of antibodies with innate immune cells facilitates cancer development. Cancer Cell 2005 7, 403-405DOI: (10.1016/j.ccr.2005.04.026) Copyright © 2005 Elsevier Inc. Terms and Conditions