mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence?

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors Kunyoo Shin, Agnes Lim, Chen.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma Fred C. Lam, Michael B. Yaffe Cancer.

The Kinase-Independent, Second Life of CDK6 in Transcription

Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Kenneth L. Scott, Scott Powers Cancer Cell

Taking the Stress out of Melanoma

Maša Alečković, Yibin Kang Cancer Cell

Nomeda Girnius, Roger J. Davis Cancer Cell

VHL Inactivation: A New Road to Senescence

Metastasis gets site specific

An Alternative Sugar Fuels AML

Volume 11, Issue 4, Pages (April 2007)

RAS unplugged: Negative feedback and oncogene-induced senescence

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

A Sweet New Role for EGFR in Cancer

Cell signaling and cancer

Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

Maria S. Soengas, E. Elizabeth Patton Cell Stem Cell

Deregulating EMT and Senescence: Double Impact by a Single Twist

Volume 26, Issue 1, Pages 1-2 (July 2014)

mTORC1: Turning Off Is Just as Important as Turning On

Volume 13, Issue 1, Pages 1-2 (January 2008)

Volume 29, Issue 3, Pages (March 2016)

PICS-ure This: Prosenescence Therapy?

Bringing IDH into the Fold

PTEN Enters the Nuclear Age

Raf-1 and Squamous Cell Carcinoma: Rok-ing the Boat

Taru Muranen, Funda Meric-Bernstam, Gordon B. Mills Cancer Cell

Common TLR5 Mutations Control Cancer Progression

The great MYC escape in tumorigenesis

Characterizing the Killer Colorectal Carcinomas

Deregulating EMT and Senescence: Double Impact by a Single Twist

The RAF Inhibitor Paradox Revisited

NOTCH and PI3K-AKT Pathways Intertwined

Bryan Krock, Nicolas Skuli, M. Celeste Simon Cell Metabolism

LKB1 and Src: Antagonistic Regulators of Tumor Growth and Metastasis

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

Kenneth L. Scott, Scott Powers Cancer Cell

BMPing Off Glioma Stem Cells

Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK

NO Signals from the Cancer Stem Cell Niche

Exercise Controls Non-Coding RNAs

Inflammation, ROS, and Mutagenesis

mTOR and Akt Signaling in Cancer: SGK Cycles In

Alex Kentsis, A. Thomas Look Cell Stem Cell

RIPK3 Slams the Brake on Leukemogenesis

Splicing and Dicing MYC-Mediated Synthetic Lethality

Khalid S. Mohammad, Theresa A. Guise Cancer Cell

Under Pressure: Stromal Fibroblasts Change Their Ways

TFIID and MYB Share a Therapeutic Handshake in AML

Volume 10, Issue 3, Pages (September 2006)

All Roads Lead to the Ribosome

Co-opted integrin signaling in ErbB2-induced mammary tumor progression

Attacking Cancer at Its Root

The Tribble with APL: A New Road to Therapy

PTENtiating CFTR for Antimicrobial Immunity

Ibrutinib Treatment of CLL: The Cancer Fights Back

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Marking Emerging β- and γδ-Selected T Cells

Presentation transcript:

mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence? George P. Souroullas, Norman E. Sharpless Cancer Cell Volume 27, Issue 1, Pages 3-5 (January 2015) DOI: 10.1016/j.ccell.2014.12.005 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Bypassing of OIS in Melanocytes and Progression to Melanoma (A) In the presence of activated BrafV600E, expression of Pten, Lkb1, and Ink4a/Arf (Cdkn2a locus) in melanocytes inhibits both mTORC1 and mTORC2 signaling, impeding cell growth and proliferation, resulting in oncogene-induced senescence. (B) Inactivating mutations of Pten, Lkb1, and Cdkn2a in postarrested melanocytes result in elevated mTORC1/2 signaling and enhanced proliferation, bypassing senescence, and promoting transformation to melanoma. Cancer Cell 2015 27, 3-5DOI: (10.1016/j.ccell.2014.12.005) Copyright © 2015 Elsevier Inc. Terms and Conditions