Volume 376, Issue 9734, Pages (July 2010)

Slides:



Advertisements
Similar presentations
TXA in trauma patients: who should we treat and when?
Advertisements

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials The Lancet Volume 386, Issue.
Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)
Venezuela: violence, human rights, and health-care realities
Volume 357, Issue 9273, Pages (June 2001)
Volume 386, Issue 9988, Pages (July 2015)
Volume 357, Issue 9257, Pages (March 2001)
Volume 359, Issue 9322, Pages (June 2002)
Pharmacogenetics and future drug development and delivery
Volume 11, Issue 4, Pages (April 2012)
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised.
Volume 378, Issue 9785, Pages (July 2011)
Volume 376, Issue 9734, Pages (July 2010)
Thank God for Richard Dawkins?
Volume 380, Issue 9836, Pages (July 2012)
Long-term effects of hormone replacement therapy
Neonatal vitamin A: time to move on?
Impact of More Restrictive Blood Transfusion Strategies on Clinical Outcomes: A Meta- analysis and Systematic Review  Shelley R. Salpeter, MD, Jacob S.
Meta-analysis of randomised controlled trials
Low-level laser therapy for neck pain
Long-term effects of hormone replacement therapy
Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled.
Volume 14, Issue 4, Pages (April 2015)
Sub-inner limiting membrane haemorrhages
Aspirin in the prevention of cancer – Author's reply
Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes:
Age-specific relevance of usual blood pressure to vascular mortality
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised.
Adjuvant chemotherapy for rectal cancer – Authors' reply
Volume 382, Issue 9888, Pages (July 2013)
Incident diabetes in clinical trials of antihypertensive drugs
Misoprostol for small bowel ulcers in patients with obscure bleeding taking aspirin and non-steroidal anti-inflammatory drugs (MASTERS): a randomised,
Ovarian cancer screening: UKCTOCS trial – Authors' reply
Mortality risk with dual antiplatelet therapy?
Volume 9, Issue 9, Pages (September 2010)
Meta-analysis of randomised controlled trials
HIV myths should not be resuscitated
Volume 375, Issue 9732, Pages (June 2010)
Michael J Goldacre, Jenny J Maisonneuve  The Lancet 
Volume 379, Issue 9812, Pages (January 2012)
Volume 12, Issue 6, Pages (June 2013)
Volume 378, Issue 9785, Pages (July 2011)
GISSI-Prevenzione trial
Volume 382, Issue 9890, Pages (August 2013)
Confessions of a journal junkie
Volume 371, Issue 9627, Pages (May 2008)
Telling it like it isn't: truth and lies in a post-9/11 world
Volume 9, Issue 4, Pages (April 2008)
Volume 382, Issue 9894, Pages (August 2013)
C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20 536 patients in the Heart Protection Study  Heart Protection.
Volume 385, Issue 9968, Pages (February 2015)
Thank God for Richard Dawkins?
Volume 373, Issue 9658, Pages (January 2009)
Department of Error The Lancet Volume 369, Issue 9564, (March 2007)
Low-technology approaches
Volume 373, Issue 9658, Pages (January 2009)
Volume 375, Issue 9719, Pages (March 2010)
Volume 375, Issue 9714, Pages (February 2010)
ACST: which subgroups will benefit most from carotid endarterectomy?
Hospital mortality and staff workload
Volume 371, Issue 9618, Pages (March 2008)
Volume 13, Issue 7, Pages (July 2014)
Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28.
Volume 368, Issue 9541, Pages (September 2006)
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised.
ECASS-II: intravenous alteplase in acute ischaemic stroke
Volume 1, Issue 2, Pages (July 2014)
Clinic attendance and disengagement of young adults with type 1 diabetes after transition of care from paediatric to adult services (TrACeD): a randomised,
Effect of consent rituals on mortality in emergency care research
Symptom-based stratification of autoimmune diseases
Presentation transcript:

Volume 376, Issue 9734, Pages 23-32 (July 2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo- controlled trial    The Lancet  Volume 376, Issue 9734, Pages 23-32 (July 2010) DOI: 10.1016/S0140-6736(10)60835-5 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2010 376, 23-32DOI: (10.1016/S0140-6736(10)60835-5) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Mortality by days from randomisation The Lancet 2010 376, 23-32DOI: (10.1016/S0140-6736(10)60835-5) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 All-cause mortality by subgroups GCS=Glasgow Coma Score. *95% CI. The Lancet 2010 376, 23-32DOI: (10.1016/S0140-6736(10)60835-5) Copyright © 2010 Elsevier Ltd Terms and Conditions