Emergence of Plasmodium falciparum triple mutant in Cambodia

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Presentation transcript:

Emergence of Plasmodium falciparum triple mutant in Cambodia Gabriele Rossi, Martin De Smet, Nimol Khim, Jean-Marie Kindermans, Didier Menard The Lancet Infectious Diseases Volume 17, Issue 12, (December 2017) DOI: 10.1016/S1473-3099(17)30635-7 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure Temporal increase in the proportion of Plasmodium falciparum triple mutants K13-WT=wild-type (3D7 type) pfKelch13 allele. K13-580Y=580Y mutant pfKelch13 allele. pfmdr1=P falciparum multidrug resistant1 gene. pfpm2=P falciparum plasmepsin2 gene. *Proportion of triple mutant significantly increased between the treatment periods (6 [7%] of 85 vs 10 [30%] of 33, p=0·002, Fisher's exact test). †Proportion of double mutant significantly decreased between the treatment periods (49 [58%] of 85 vs 11 [33%] of 33, p=0·02, Fisher's exact test). The Lancet Infectious Diseases 2017 17, DOI: (10.1016/S1473-3099(17)30635-7) Copyright © 2017 Elsevier Ltd Terms and Conditions