MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome Eleanore S.J. Kröner, Arthur J.H.A.

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Presentation transcript:

MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome Eleanore S.J. Kröner, Arthur J.H.A. Scholte, Patrick J.H. de Koning, Pieter J. van den Boogaard, Lucia J.M. Kroft, Rob J. van der Geest, Yvonne Hilhorst-Hofstee, Hildo J. Lamb, Hans-Marc J. Siebelink, Barbara J.M. Mulder, Maarten Groenink, Teodora Radonic, Ernst E. van der Wall, Albert de Roos, Johan H.C. Reiber, Jos J.M. Westenberg International Journal of Cardiology Volume 167, Issue 6, Pages 2977-2982 (September 2013) DOI: 10.1016/j.ijcard.2012.08.057 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Representation of image acquisition and analysis in a MFS patient. Regional aortic luminal area and regional PWV were obtained from MRI data. Fig. 1A. Maximum-intensity-projection of contrast-enhanced (CE) MRA data of an MFS patient. Five aortic segments were evaluated: ascending aorta (S1), aortic arch (S2), thoracic descending aorta (S3) suprarenal abdominal aorta (S4) and infrarenal abdominal aorta (S5). Fig. 1B. The CE-MRA image analysis was performed using in-house developed LAVA software with automated centerline detection and 3D deformable modeling. Fig. 1C. From CE-MRA data, cross-sectional luminal area was determined at 200 equidistantly-spaced sample points along the aortic centerline. For both baseline and 2-year follow-up, the mean lumen area per segment was determined. Fig. 1D. PWV was obtained from two-directional, three-slice in-plane velocity-encoded MRI data using in-house developed MASS software, by calculating the relation between pulse wave arrival time at 200 equidistantly-spaced sample points along the aortic centerline and the position of these sample points along the centerline (Fig. 1E). The centerline of PWV analysis was registered manually to the MRA centerline, and MRA centerline at baseline and follow-up were also manually registered. Regional PWV was determined for each of the five aortic segments. International Journal of Cardiology 2013 167, 2977-2982DOI: (10.1016/j.ijcard.2012.08.057) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions