Rashmi B. Prasad, Leif Groop Cell Metabolism

Slides:

Advertisements

Similar presentations

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Advertisements

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Volume 5, Issue 3, Pages (March 2016)

Untangling P-Bodies: Dissecting the Complex Web of Interactions that Enable Tiered Control of Gene Expression Christopher J. Kershaw, Mark P. Ashe Molecular.

Does Reduced Creatine Synthesis Protect against Statin Myopathy?

Ghrelin—a new player in glucose homeostasis?

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

Hubert Kolb, Matthias von Herrath Cell Metabolism

Molecular Therapy - Methods & Clinical Development

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Does Hypothalamic Inflammation Cause Obesity?

Pancreatic β cells: Responding to the matrix

Volume 26, Issue 3, Pages e3 (September 2017)

Germ layers: Cell lineages

Serotonin and the Orchestration of Energy Balance

Volume 23, Issue 3, Pages (March 2016)

SUMOylation Places LRH-1 in PROXimity to Lipid Metabolism

Safia Costes, Peter C. Butler Cell Metabolism

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Insulin and glucagon secretion: nondiabetic and diabetic subjects.

A Clock Ticks in Pancreatic β Cells

Gal3 Links Inflammation and Insulin Resistance

From Embryonic Stem Cells to β-Cells: New Hope for Diabetics?

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

Type 1 Diabetes and MicroRNA: It’s Complicated

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Michael Downes, Christopher Liddle Cell Metabolism

High T Gives β Cells a Boost

Jelena Kolic, James D. Johnson Cell Metabolism

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

The CAMplexities of Central Ghrelin

Volume 3, Issue 6, Pages (June 2006)

Autophagy: A Sweet Process in Diabetes

Chad M. Trent, Martin J. Blaser Cell Metabolism

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Stop that Noise and Turn Up the Antisense Transcription

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Untangling P-Bodies: Dissecting the Complex Web of Interactions that Enable Tiered Control of Gene Expression Christopher J. Kershaw, Mark P. Ashe Molecular.

Viable Rat-Mouse Chimeras: Where Do We Go from Here?

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 27, Issue 4, Pages (April 2018)

Insulin Action under Arrestin

Volume 4, Issue 5, Pages 2-3 (October 2006)

Volume 11, Issue 4, Pages (April 2010)

Volume 25, Issue 3, Pages (March 2017)

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis Sarah H. Bates, Rohit N. Kulkarni, Matthew.

Fly-let Biology and the High Protein/Low Carb Diet

Volume 24, Issue 4, Pages (October 2016)

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

Iron Sensing as a Partnership: HFE and Transferrin Receptor 2

Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice Christelle Ratineau,

Ann Marie Schmidt, Kathryn J. Moore Cell Metabolism

Treating Diabetes by Blocking a Vascular Growth Factor

Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level Wei-Lin Qiu, Yu-Wei Zhang, Ye.

Grg3 is expressed in most β-cells but less frequently in α-cells.

Joan Goulley, Ulf Dahl, Nathalie Baeza, Yuji Mishina, Helena Edlund

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Volume 163, Issue 2, (October 2015)

Should I Stay or Should I Go: A Clash of α-Cell Identity

Many Roads Lead to the Lipid Droplet

Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi

Volume 19, Issue 4, Pages (April 2014)

Estrogens and Obesity: Is It All in Our Heads?

Presentation transcript:

Single-Cell Sequencing of Human Pancreatic Islets—New Kids on the Block Rashmi B. Prasad, Leif Groop Cell Metabolism Volume 24, Issue 4, Pages 523-524 (October 2016) DOI: 10.1016/j.cmet.2016.09.012 Copyright © 2016 Terms and Conditions

Figure 1 Pancreas Single-Cell Transcriptomics (A) Various cell types in the pancreas. (B) Overlap of gene expression in α and β in Xin et al. and Segerstolpe et al. (C) Expression of lead gene (glucagon, GCG; insulin, INS; pancreatic polypeptide, PPY; somatostatin, SST; ghrelin, GHRL) (left bar) compared with expression of all other genes in each of the islet cell types. Data from Segerstolpe et al. (2016). Cell Metabolism 2016 24, 523-524DOI: (10.1016/j.cmet.2016.09.012) Copyright © 2016 Terms and Conditions