Invasive Inflammatory Myofibroblastic Tumor of the Lung

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Presentation transcript:

Invasive Inflammatory Myofibroblastic Tumor of the Lung Daniel A. van den Heuvel, MD, Ruth G. Keijsers, MD, Hendrik W. van Es, MD, PhD, Gerben P. Bootsma, MD, PhD, Peter C. de Bruin, MD, PhD, Franz M. Schramel, MD, PhD, Johannes P. van Heesewijk, MD, PhD Journal of Thoracic Oncology Volume 4, Issue 7, Pages 923-926 (July 2009) DOI: 10.1097/JTO.0b013e3181a76e28 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Posteroanterior chest radiograph showing a mass-like consolidation in the left lower lobe with enlargement of the left hilum and a large smooth calcification posterior to the heart. Journal of Thoracic Oncology 2009 4, 923-926DOI: (10.1097/JTO.0b013e3181a76e28) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Axial contrast-enhanced computed tomography (CT) scan shows a large heterogeneous mass in the left lower lobe with one large and several smaller calcifications. (A) There is no interface with the wall of the left ventricle (black arrow) and pleura. (B) Coronal reconstruction demonstrating hilar and upper lobe involvement and a large solid central calcification corresponding with the calcification seen on the chest radiograph (asterisk). The white arrow is pointing toward one of the supplying arteries branching from the descending aorta. S, spleen; L, liver. Journal of Thoracic Oncology 2009 4, 923-926DOI: (10.1097/JTO.0b013e3181a76e28) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Gross pathology left lung resection specimen. There is a white, firm-elastic tumor (diameter 11 cm) in the lower lobe with extension into the upper lobe (arrowheads). The mass contains a focal calcification that correlates with the calcification seen on the imaging studies (asterisk). Diaphragm and pericardial tissue can not be recognized properly in this picture. The arrow is pointing toward the upper lobe bronchus. LUL, left upper lobe; LLL, left lower lobe. Journal of Thoracic Oncology 2009 4, 923-926DOI: (10.1097/JTO.0b013e3181a76e28) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Microscopy (hematoxylin-eosin stain, magnification: original ×200) showing a spindle cell proliferation set in a collagenous stroma with an inflammatory component of lymphocytes and plasma cells. Journal of Thoracic Oncology 2009 4, 923-926DOI: (10.1097/JTO.0b013e3181a76e28) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions