Urea channel inhibitors: a new functional class of aquaretics

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Urea channel inhibitors: a new functional class of aquaretics Mark A. Knepper, Carlos A. Miranda  Kidney International  Volume 83, Issue 6, Pages 991-993 (June 2013) DOI: 10.1038/ki.2013.94 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Roles of urea channels in the process responsible for accumulation of urea in the renal inner medulla.See article text for explanation. UT-B, UT-A1, UT-A2, and UT-A3 are urea channel isoforms. AVR, ascending vasa recta; DVR, descending vasa recta; IM, inner medulla; IMCD, inner medullary collecting duct; IS-OM, inner stripe of outer medulla; OS-OM, outer stripe of outer medulla. Kidney International 2013 83, 991-993DOI: (10.1038/ki.2013.94) Copyright © 2013 International Society of Nephrology Terms and Conditions

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