Histological staining reveals glomeruloid-like bodies in the forebrain and spinal cord of Gpr124−/− mice. Histological staining reveals glomeruloid-like.

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Jeffrey T Wigle, Guillermo Oliver Cell

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Histological staining reveals glomeruloid-like bodies in the forebrain and spinal cord of Gpr124−/− mice. Histological staining reveals glomeruloid-like bodies in the forebrain and spinal cord of Gpr124−/− mice. (A) Whole mount CD31-vessel stained surface glomeruloids attached to the PNVP. (B) Glomeruloids in the region of the ganglionic eminence at E10.5. Nestin staining (red) highlights the neuroepithelium. (C) At E11.5, vessels in WT mice penetrate the neuroepithelium and begin to form a subventricular vascular plexus (SVP), whereas corresponding vessels in Gpr124−/− mice form glomeruloids, which increase in size with time. (D) Glomeruloids (arrowheads) in the ventral spinal cord of Gpr124−/− mice. (E) NG2+ pericytes (red) closely associated with isolectin-labeled ECs (green) in the pallium. Arrowheads in E indicate an endothelial stalk. ISL, isolectin; LN, laminin; V, ventricle. (Scale bars, 100 μm, unless stated otherwise.)‏ Mike Cullen et al. PNAS 2011;108:14:5759-5764 ©2011 by National Academy of Sciences