Boosting Bacterial Metabolism to Combat Antibiotic Resistance

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Presentation transcript:

Boosting Bacterial Metabolism to Combat Antibiotic Resistance Prerna Bhargava, James J. Collins Cell Metabolism Volume 21, Issue 2, Pages 154-155 (February 2015) DOI: 10.1016/j.cmet.2015.01.012 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Exogenous Addition of Metabolites Enhances Antibiotic Uptake, Leading to Cell Death (A) Antibiotic-resistant cells have lower metabolite abundances, leading to reduced PMF, inhibited drug uptake, and survival. (B) Exogenous addition of alanine and/or glucose can enhance drug uptake and restore cell sensitivity. Cell Metabolism 2015 21, 154-155DOI: (10.1016/j.cmet.2015.01.012) Copyright © 2015 Elsevier Inc. Terms and Conditions