Immobile BCRs: The Safety on the Signal Trigger

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Presentation transcript:

Immobile BCRs: The Safety on the Signal Trigger Yoshiteru Sasaki, Tomohiro Kurosaki Immunity Volume 32, Issue 2, Pages 143-144 (February 2010) DOI: 10.1016/j.immuni.2010.02.007 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 The Actin Cytoskeleton Controls BCR Diffusion Dynamics and Signaling BCRs in ezrin- and actin-defined network-rich regions are immobile and exist together with inhibitory receptors and signaling molecules such as CD22 and SHP1 (left panel). In contrast, BCRs in actin cytoskeleton-poor regions are highly mobile and have a high increased interaction with positive regulators such as CD19 and Src-family kinase (right panel). Immunity 2010 32, 143-144DOI: (10.1016/j.immuni.2010.02.007) Copyright © 2010 Elsevier Inc. Terms and Conditions