Loss of glomerular ESL contributes to increased glomerular albumin sieving coefficient, and modification of ESL improves glomerular albumin sieving coefficient,

Slides:

Advertisements

Similar presentations

Evidence for Shear Stress–Mediated Dilation of the Internal Carotid Artery in HumansNovelty and Significance by Howard H. Carter, Ceri L. Atkinson, Ilkka.

Advertisements

Pioglitazone treatment prevents TRPC6 overexpression and podocyte injury in the adriamycin (ADRIA)–induced nephropathy rat model for FSGS. ADRIA-induced.

Inhibition of ILK by QLT-0267 reduces β-catenin accumulation and inhibits Snail1 expression in obstructive nephropathy. Inhibition of ILK by QLT-0267 reduces.

Sildenafil does not prevent TRPC6 overexpression and podocyte injury in adriamycin (ADRIA)–challenged podocyte-specific PPAR-γ KO mice. Sildenafil does.

Relationship between urinary TNF-α and RANTES excretion

Components of the yield trend.

Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6 expression. Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6.

Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.

ESL of mesenteric microvessels is compromised in old MWF rats.

Several microRNAs are differentially expressed in the glomeruli between different types of kidney disease. Several microRNAs are differentially expressed.

Ventilatory and cerebrovascular responses to hyperoxic hypercapnia.

Renal microvascular injury 6 months after induction of JG cell-specific Gsα knockout. Renal microvascular injury 6 months after induction of JG cell-specific.

The proportion of DCD donor kidneys discarded was correlated with the proportion of NBD donor kidneys discarded within DSAs (Pearson correlation coefficient.

VEGF signals via a paracrine loop to VEGFR-2 in the glomerulus.

Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome.

Whole body deletion of VEGFR-2 results in vascular defects, with glomerular thrombotic microangiopathy. Whole body deletion of VEGFR-2 results in vascular.

Andrew K Finn, Jennifer L Whistler Neuron

SS-31 reduces inflammation after acute renal ischemia.

Further exploration of the risk factor associations with either the first or subsequent congestive heart failure (CHF) events using the Prentice, Williams,

Cristina Márquez, Scott M. Rennie, Diana F. Costa, Marta A. Moita

Growth hormone promotes glomerular lipid accumulation in bGH mice

Phenotypic variation of sake yeast strains.

Trend of overall improvement in CKD risk categories after bariatric surgery using year 1 post-surgery as baseline. Trend of overall improvement in CKD.

(A through C) Mean eGFR during follow-up according to treatment assignment in patients with normoalbuminuria (A), microalbuminuria (B), and macroalbuminuria.

Young people drink significantly less frequently than older people (A), but drink significantly more on each drinking day (panel B). Young people drink.

Urine ammonia is highly correlated with plasma K

Thirty-day survival curves for the rapid versus slow correction rate groups are not significantly different. Thirty-day survival curves for the rapid versus.

Contribution of tubular injury to loss of remnant kidney function

Synaptopodin expression is also in cells on Bowman’s capsule in juvenile human kidney. Synaptopodin expression is also in cells on Bowman’s capsule in.

ILK knockdown increases the survival of PKD mice.

Capillary recruitment is associated with albuminuria.

Figure 5. Tissue uptake of circulating 125I-β2-m.

The insulin tolerance test at week 18.

Box plots showing the relative difference in distribution of mtDNA copy number per cell between patients with ESRD and healthy control subjects frequency.

Figure 3. Effect of spironolactone or albumin conjugation on the vasoconstrictor action of aldosterone in afferent arterioles (left) and efferent arterioles.

Mineral content analysis by SEM-EDX.

Figure 4. The N:M ratio is significantly increased in patients with ALS and correlates with disease progression The N:M ratio is significantly increased.

Association between hospital-level diagnostic testing and admission percentage for patients with AGE at 34 US children’s hospitals. Association between.

Variation in rosette leaf area and leaf surface temperatures in Arabidopsis accessions and Arabidopsis lines ectopically expressing different ABA receptors.

A glomerulus from a patient who developed nephrotic syndrome while receiving a nonsteroidal anti-inflammatory drug for arthritis. A glomerulus from a patient.

Arginine-to-lysine mutations conferring TRIM22 restriction and lysine-to-arginine mutations causing loss of TRIM22 restriction. Arginine-to-lysine mutations.

In-hospital outcomes: community- versus hospital-acquired AKI

Lifestyle intervention was associated with improved cardiorespiratory fitness. Lifestyle intervention was associated with improved cardiorespiratory fitness.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

More women are affected than men in X-linked Alport syndrome.

Insulin sensitivity in athletes and sedentary normal-weight and obese, young, and old individuals. Insulin sensitivity in athletes and sedentary normal-weight.

(A) Hemoglobin A1c (HbA1c) values at baseline and after treatment with anagliptin in 20 participants at 12 and 24 weeks. (B) Urinary albumin to creatinine.

Volume 66, Issue 2, Pages (August 2004)

Atrasentan reduces albuminuria in diabetic apoE KO mice.

Glucose stimulates GLP-1 secretion from the perfused rat intestine by a dose- and absorption-dependent manner. Glucose stimulates GLP-1 secretion from.

Observed versus expected associations between the FGGRS and IMT

The development of regional ventricular dysfunction as measured by regional wall motion abnormalities (RWMA; abnormal regions) was associated with a greater.

Basic structure of the glomerulus and the glomerular filtration barrier. Basic structure of the glomerulus and the glomerular filtration barrier. (A) Each.

Responses measured by BOLD fMRI in areas V1, V2, V3, and MT+ as two subjects (S2, gray; S3, black) switched between the speed and the contrast discrimination.

A, Elevation in the amount of solution consumed (without sucrose or salt) during the depletion test following sodium depletion compared with the baseline.

Local translation and RhoA activity are required for the axon growth-inhibiting effects of CSPGs. A, Axonal application of cycloheximide (CHX) or anisomycin.

Distribution of NE- and KCl-responsive precursor cells along the septotemporal axis of the hippocampus. Distribution of NE- and KCl-responsive precursor.

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced.

Spatial frequency preferences of contralateral responses is higher than ipsilateral responses in AAV-SynGCaMP6s-injected mice. Spatial frequency preferences.

Higher spatial frequency tuning of the contralateral responses also found in anesthetized animals. Higher spatial frequency tuning of the contralateral.

Socially isolated SV40 Tag mice develop significantly larger mammary gland tumors. Socially isolated SV40 Tag mice develop significantly larger mammary.

(D) Systolic blood pressure (BP) values at baseline and after treatment with anagliptin in 20 participants at 12 and 24 weeks. . (D) Systolic blood pressure.

Relationship between excess fluid, as determined by the difference between measured and estimated body water, and plasma albumin (R = −0.40, P = 0.011).

Immunohistochemical and immunogluorescence analysis of renal biopsies showing significant C5b-9, C4d and C3c deposition but almost absent Bb deposition.

MEP amplitude ratios for pre- and post-A-tDCS of the ABA-6HRS control group. MEP amplitude ratios for pre- and post-A-tDCS of the ABA-6HRS control group.

Separation in achieved BP levels between the two intervention groups in the SPRINT participants with CKD. The broken line and open circles denote the intensive.

Fig. 6 Stabilization of hippocampal signaling over sleep.

Renal hemodynamics. Renal hemodynamics. GFR (A), effective renal plasma flow (ERPF; B), and filtration fraction (FF; C) in patients with diabetes and with.

Perception of indications for referral to a nephrologist among internal medicine residents according to the postgraduate year (PGY). Perception of indications.

Presentation transcript:

Loss of glomerular ESL contributes to increased glomerular albumin sieving coefficient, and modification of ESL improves glomerular albumin sieving coefficient, in old MWF rats. Loss of glomerular ESL contributes to increased glomerular albumin sieving coefficient, and modification of ESL improves glomerular albumin sieving coefficient, in old MWF rats. (A) In healthy young MWF rats, glomerular albumin sieving coefficient values (Θalbumin) of individual glomeruli (open circles; open square represents mean ± SEM) were elevated after exposure to neuraminidase in every glomerulus (black circles; black square represents mean ± SEM). #P<0.05 versus baseline (paired t test). In contrast, higher Θalbumin values in old MWF rats (open circles; open square represents mean ± SEM) were not significantly elevated any further after neuraminidase exposure (black circles; black square represents mean ± SEM) ns, P>0.05 versus baseline (paired t test). (B) Binding of WGA lectin to the ESL (hashed bars) significantly reduced Θalbumin in old MWF rats (black bar). A similar, nonsignificant trend toward reduced Θalbumin after lectin binding was also observed in young MWF rats (open bar). *P<0.05; ns, P>0.05 versus baseline (one-way ANOVA, Bonferroni). (C) Θalbumin for individual glomeruli (gray circles, young MWF; black circles, old MWF) were significantly correlated with the percentage of glomerular capillary wall sites with ESL cover in the same glomerulus (Pearson r=−0.59; P<0.005). Andrew H.J. Salmon et al. JASN 2012;23:1339-1350 ©2012 by American Society of Nephrology