PI3K Regulatory Subunits Lose Control in Cancer

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PI3K Regulatory Subunits Lose Control in Cancer Inma Martin-Berenjeno, Bart Vanhaesebroeck Cancer Cell Volume 16, Issue 6, Pages 449-450 (December 2009) DOI: 10.1016/j.ccr.2009.11.017 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Cancer Mutations in PI3K Family Members The left panel shows the frequency of mutation in cancer in the different PI3K family members. The right panel shows the location of mutations (indicated by arrowheads) in p110α and p85α. The mutations that are discussed in the text are spelled out. Not shown are the p55α and p50α proteins, which are encoded by transcripts from the PIK3R1 gene through alternative promoter usage. Compared to p85α, p55α and p50α contain the same SH2 domains and the iSH2 domain but a smaller N-terminal extension. Cancer Cell 2009 16, 449-450DOI: (10.1016/j.ccr.2009.11.017) Copyright © 2009 Elsevier Inc. Terms and Conditions