GPR124 expression in endothelial cells is responsible for the phenotypes observed in Gpr124−/− mice. GPR124 expression in endothelial cells is responsible.

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GPR124 expression in endothelial cells is responsible for the phenotypes observed in Gpr124−/− mice. GPR124 expression in endothelial cells is responsible for the phenotypes observed in Gpr124−/− mice. (A) Macroscopic hemorrhaging in the E15.5 embryonic brain was obvious in the Gpr124−/flox; Tg(Tie2-Cre) mice but was absent from the Gpr124+/flox; Tg(Tie2-Cre) mice. (B) The pallium was notably thinner in the E15.5 embryonic brain of Gpr124−/flox; Tg(Tie2-Cre) mice. (C) Isolectin-B4 and NG2+ glomeruloids were found in the lateral ventricular wall in the region adjacent to the ganglionic eminence of E12.5 Gpr124−/flox; Tg(Tie2-Cre) brains. Isolectin positive, NG2+ macrophages were frequently observed in the ventricular wall of both the global Gpr124−/− and Gpr124−/flox; Tg(Tie2-Cre) brains and are particularly abundant in the E15.5 Inset (C, far Right), which is taken from the region shown in B. Mike Cullen et al. PNAS 2011;108:14:5759-5764 ©2011 by National Academy of Sciences