Histological features of murine DSS-induced colitis.

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Histological features of murine DSS-induced colitis. Histological features of murine DSS-induced colitis. (A,B) Histology images of colon cross-sections from control (A) and dextran sulfate sodium (DSS)-treated (B) mice. The diagram under each panel illustrates an outline of a mouse colon cross-section with boxes A and B indicating the histological regions shown in panels A and B, respectively. Mir29-knockout mice from a Black6 background were treated either with water (control animals) or with 1.5% DSS for 8 days prior to examination. Whereas the cross-section of the colon wall from a control mouse shows normal morphology (A), the colon of the DSS-treated mouse (B) shows alterations in the mucosal epithelium such as cell necrosis, and loss of structure of both villi and intestinal crypts (C; indicated by arrowhead). In addition, infiltration of immune cells such as macrophages, neutrophils, eosinophils and lymphocytes (indicated with arrowheads) is found in the colonic lamina propria (L) and submucosa (SM), indicative of the inflammatory status of the DSS-treated mouse. C, intestinal crypts; G, goblet cells; L, lamina propria; ME, muscularis externa; MM, muscularis mucosae; MT: muscularis tunics; SM: submucosa; V: villi. Thi Loan Anh Nguyen et al. Dis. Model. Mech. 2015;8:1-16 © 2015. Published by The Company of Biologists Ltd