Volume 78, Pages (January 2018)

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Volume 78, Pages 70-74 (January 2018) Diffusion Tensor Imaging as a Biomarker to Differentiate Acute Disseminated Encephalomyelitis From Multiple Sclerosis at First Demyelination Wint Yan Aung, BA, Parinaz Massoumzadeh, PhD, Safa Najmi, MD, Amber Salter, PhD, Jodi Heaps, PhD, Tammie L.S. Benzinger, MD, PhD, Soe Mar, MD Pediatric Neurology Volume 78, Pages 70-74 (January 2018) DOI: 10.1016/j.pediatrneurol.2017.09.016 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Flow diagram outlining the study design and analysis. ADEM, acute disseminated encephalomyelitis; CIS, clinically isolated syndrome; DTI, diffusion tensor imaging; FLAIR, fluid-attenuated inversion recovery; IPMSSG, International Pediatric MS Study Group; MRI, magnetic resonance imaging; MS, multiple sclerosis; ROI, region of interest. (The color version of this figure is available in the online edition.) Pediatric Neurology 2018 78, 70-74DOI: (10.1016/j.pediatrneurol.2017.09.016) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Representative images (FLAIR and DTI) and selected ROI of a 15-year-old female patient with MS at baseline and age-matched control subject. (A) ROI selection based on hyperintensity abnormality on registered FLAIR image, (B) registered FLAIR image of respective age-matched control, (C) fractional anisotropy, (D) mean diffusivity, (E) axial diffusivity, (F) radial diffusivity of the MS patient. DTI measurements were obtained from ROIs using ImageJ. DTI, diffusion tensor imaging; FLAIR, fluid-attenuated inversion recovery; MS, multiple sclerosis; ROI, region of interest. (The color version of this figure is available in the online edition.) Pediatric Neurology 2018 78, 70-74DOI: (10.1016/j.pediatrneurol.2017.09.016) Copyright © 2017 Elsevier Inc. Terms and Conditions