Mitchell Schnall MD, PhD The Diagnostic Cockpit of the Future: Radiologist/Physician Perspective Mitchell Schnall MD, PhD Welcome Diverse group – Pros and Cons Caveat that, while I represent industry, I know most about is imaging Todays workshop about converging on a few actionable items.

Diagnostics Enables Precision Medicine Takes advantage of information about each patient to fit them into sub-populations for a more precise approach to disease management Population Sub population 1 Treatment 1 Sub population 2 Treatment 2 Sub population 3 Treatment 3 Sub population 4 Treatment 4

Current Status: Diagnostic Silos without clear integration tools Other “omics” Metabolomics Microbi “ome” Social Media “ome” Anatomic Imaging Molecular Imaging Molecular Diagnostics Histology

Range of diagnostic considerations

Integrated Diagnostics Clinical Data

Challenges to the diagnostic cockpit Evolution from art of diagnostics to data science Technical integration of data streams Data Standards Unstructured data (assessments and outcomes) Population trends vs individual patient decision Complexity of clinical diagnostics