Volume 10, Issue 1, Pages 1-10 (January 2018) Dose-Dependent Effects of AbobotulinumtoxinA (Dysport) on Spasticity and Active Movements in Adults With Upper Limb Spasticity: Secondary Analysis of a Phase 3 Study  Michael W. O’Dell, MD, Allison Brashear, MD, Robert Jech, MD, PhD, Thierry Lejeune, MD, PhD, Philippe Marque, MD, PhD, Djamel Bensmail, MD, PhD, Ziyad Ayyoub, MD, David M. Simpson, MD, Magali Volteau, PhD, Claire Vilain, MD, Philippe Picaut, PharmD, Jean Michel Gracies, MD, PhD  PM&R  Volume 10, Issue 1, Pages 1-10 (January 2018) DOI: 10.1016/j.pmrj.2017.06.008 Copyright © 2018 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 1 Change from baseline of Tardieu Scale parameters and of active range of motion week 4 postinjection in (A) extrinsic finger flexors, (B) wrist flexors, and (C) elbow flexors. Dose groups were as follows (lowest to highest dose): 500 U/non-PTMG, 500 U/PTMG, 1000 U/non-PTMG, and 1000 U/PTMG. Standard deviations and mean change from baseline values are detailed in Table 3. PTMG = primary targeted muscle group; XV1 = passive range of motion; XV3 = angle of catch at fast speed; XA = active range of motion. PM&R 2018 10, 1-10DOI: (10.1016/j.pmrj.2017.06.008) Copyright © 2018 American Academy of Physical Medicine and Rehabilitation Terms and Conditions