A Genomewide Screen of 345 Families for Autism-Susceptibility Loci

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A Genomewide Screen of 345 Families for Autism-Susceptibility Loci Amanda L. Yonan, Maricela Alarcón, Rong Cheng, Patrik K.E. Magnusson, Sarah J. Spence, Abraham A. Palmer, Adina Grunn, Suh- Hang Hank Juo, Joseph D. Terwilliger, Jianjun Liu, Rita M. Cantor, Daniel H. Geschwind, T. Conrad Gilliam  The American Journal of Human Genetics  Volume 73, Issue 4, Pages 886-897 (October 2003) DOI: 10.1086/378778 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint MLS results from Mapmaker/Sibs ASP analysis, shown by chromosome. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thin lines represent the narrow disease classification; thick lines represent the broad disease classification (see the “Families and Methods” section). Black bars below the X-axis show regions with dense microsatellite marker coverage. The American Journal of Human Genetics 2003 73, 886-897DOI: (10.1086/378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Multipoint MLS results from Mapmaker/Sibs ASP analysis, shown by chromosome. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thin lines represent the narrow disease classification; thick lines represent the broad disease classification (see the “Families and Methods” section). Black bars below the X-axis show regions with dense microsatellite marker coverage. The American Journal of Human Genetics 2003 73, 886-897DOI: (10.1086/378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Comparison of the three stages of ASP analysis for selected chromosomes. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thick red lines represent analysis of updated stage 1 (110 families) (see the “Families and Methods” section); hatched blue lines represent analysis of stage 2 (156 families); and black lines represent analysis of stage 3 (345 families). The American Journal of Human Genetics 2003 73, 886-897DOI: (10.1086/378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions