Mrs. Zuccarelli Biology 9H Modern Genetics Mrs. Zuccarelli Biology 9H

Griffith: 1928 Streptococcus studies Objective A

Objective A Avery, McCloud, & McCarty: 1944 Establish the “transforming factor” Objective A

Objective A Hershey & Chase: 1952 Viral analysis of the genetic material Objective A

Objective A Watson & Crick: 1953 Rosalind Franklin: 1953 Nobel prize (1962) for structure of DNA Rosalind Franklin: 1953 X-ray crystallography Objective A

Objective B

Objective C DNA is antiparallel – one strand is “right side up” the other is “upside down”

Objective D: Animations DNA Replication Animation (Hard) DNA Replication Animation (Medium) Build yourself: DNA Replication Objective D: Animations

Objective D

Objective D

Objective E One Gene, One Polypeptide Hypothesis: Each gene on the DNA directs the synthesis of a particular polypeptide chain (protein) Objective E

Objective F

Objective G: Animations Transcription (Medium) Transcription (Hard) Translation (Hard) Translation (Medium) Build yourself (transcription / translation) Objective G: Animations

Objective G

Objective G

Objective G

Objective G

Objective H

Objective I

Objective I

Objective J

Objective K

Objective K

Objective K Chromosomal Mutations Translocation Addition Inversion Deletion Non-Disjunction Polyploidy Objective K

Objective L

Objective L

Objective M

Objective M

Objective M

Objective M

Objective M

Objective M

Objective M

Objective N

Objective O

Objective O

Objective P A SPECIAL REPORT ON CLONING By CHARLES KRAUTHAMMER Featured in Time Magazine March 10, 1997 Dolly was cloned in 1997 by Ian Wilmut, 277 attempts, 29 embryos transferred, only 1 lamb born Click and Clone!! Objective P

Objective P

Objective Q

Objective R

Electrophoresis Objective U