Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,

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Presentation transcript:

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman, MPH, Thomas A. Platts-Mills, MD, Lisa Workman, BA, Joanne E. Sordillo, ScD, Carlos A. Camargo, MD, DrPH, Matthew W. Gillman, MD, SM, Diane R. Gold, MD, MPH, Augusto A. Litonjua, MD, MPH Journal of Allergy and Clinical Immunology Volume 133, Issue 5, Pages 1373-1382 (May 2014) DOI: 10.1016/j.jaci.2013.11.040 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Associations between maternal intake of food allergens during the first trimester and current allergy and asthma outcomes at mid-childhood. Models were adjusted for child age, sex, breast-feeding history, parental atopy, and maternal education. *Food allergy defined as sensitization to the respective food AND EpiPen prescribed, except for peanut allergy, which was more specifically defined by convincing symptoms of a peanut allergic reaction (history of peanut allergy AND a cutaneous, respiratory, cardiovascular, gastrointestinal, and/or anaphylactic symptom following peanut ingestion). †Food sensitization defined as an sIgE level of 0.35 kU/L or more to the respective food. Journal of Allergy and Clinical Immunology 2014 133, 1373-1382DOI: (10.1016/j.jaci.2013.11.040) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Associations between maternal intake of food allergens during the second trimester and current allergy and asthma outcomes at mid-childhood. Models were adjusted for child age, sex, breast-feeding history, parental atopy, and maternal education. *Food allergy defined as sensitization to the respective food AND EpiPen prescribed, except for peanut allergy, which was more specifically defined by convincing symptoms of a peanut allergic reaction (history of peanut allergy AND a cutaneous, respiratory, cardiovascular, gastrointestinal, and/or anaphylactic symptom following peanut ingestion). †Food sensitization defined as an sIgE level of 0.35 kU/L or more to the respective food. Journal of Allergy and Clinical Immunology 2014 133, 1373-1382DOI: (10.1016/j.jaci.2013.11.040) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Food allergen sensitization and food allergy among participants of the Project Viva birth cohort. A, Distribution of food allergen sIgE levels among the 616 participants for whom sIgE levels were measured. B, Percent of study population sensitized with and without allergy. The total height of each bar represents the prevalence of sensitization to each food allergen among the 616 participants for whom sIgE levels were measured. Each bar is then divided into 2 parts—the red part representing the proportion sensitized to the food allergen and food allergic, and the blue part representing the proportion sensitized to the food allergen and not food allergic. Journal of Allergy and Clinical Immunology 2014 133, 1373-1382DOI: (10.1016/j.jaci.2013.11.040) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Prevalences of single and multiple food allergen sensitization. Numbers are percent of study sample with mid-childhood data and sIgE levels (N = 616). Journal of Allergy and Clinical Immunology 2014 133, 1373-1382DOI: (10.1016/j.jaci.2013.11.040) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Cross-sectional associations between food allergy and current asthma, current allergic rhinitis, and current atopic dermatitis at mid-childhood. Models were adjusted for child age, sex, breast-feeding history, parental atopy, and maternal education. Association for egg allergy and atopic dermatitis not shown given 0 subjects with both conditions at mid-childhood. Journal of Allergy and Clinical Immunology 2014 133, 1373-1382DOI: (10.1016/j.jaci.2013.11.040) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions