Relief of Incident Dyspnea in Palliative Cancer Patients: A Pilot, Randomized, Controlled Trial Comparing Nebulized Hydromorphone, Systemic Hydromorphone,

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Relief of Incident Dyspnea in Palliative Cancer Patients: A Pilot, Randomized, Controlled Trial Comparing Nebulized Hydromorphone, Systemic Hydromorphone, and Nebulized Saline Margaret A. Charles, PhD, Liz Reymond, MBBS(Hons), PhD, FAChPM, Fiona Israel, MCouns Journal of Pain and Symptom Management Volume 36, Issue 1, Pages 29-38 (July 2008) DOI: 10.1016/j.jpainsymman.2007.08.016 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Flow of patients through the study. NH-nebulized hydromorphone; SH-systemic hydromorphone; NS-nebulized saline. Journal of Pain and Symptom Management 2008 36, 29-38DOI: (10.1016/j.jpainsymman.2007.08.016) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Mean breathlessness with treatments: NH=nebulized hydromorphone, SH=systemic hydromorphone, NS=nebulized saline. Journal of Pain and Symptom Management 2008 36, 29-38DOI: (10.1016/j.jpainsymman.2007.08.016) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 (a) Respiratory rate, (b) pulse rate, (c) peripheral oxygen saturation. Objective indicators of respiratory status across treatments and time periods. NH=nebulized hydromorphone, SH=systemic hydromorphone, NS=nebulized saline. Journal of Pain and Symptom Management 2008 36, 29-38DOI: (10.1016/j.jpainsymman.2007.08.016) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions