Jagadeesh Bayry, Jean-François Gautier Cell Metabolism

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

The ART of Lowering Ceramides

Does Reduced Creatine Synthesis Protect against Statin Myopathy?

Immunological Goings-on in Visceral Adipose Tissue

Metabolic Acceleration in Human Evolution

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Metabolism by Remote Control

Nicholas A. Bokulich, Martin J. Blaser Cell Metabolism

Boosting Bacterial Metabolism to Combat Antibiotic Resistance

Can Your Microbiome Tell You What to Eat?

Serotonin and the Orchestration of Energy Balance

Volume 24, Issue 3, Pages (September 2016)

George Dailey, MD Mayo Clinic Proceedings

Getting to the heart of COX-2 inhibition

Volume 21, Issue 6, Pages (December 2017)

Assessment of Feeding Behavior in Laboratory Mice

Gene therapy in haematology and oncology

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

Wenlian Qiao, Peter W. Zandstra Cell Stem Cell

Type 1 Diabetes and MicroRNA: It’s Complicated

Gene therapy—where are we?

B. Brett Finlay, Grant McFadden Cell

Getting to the heart of COX-2 inhibition

Putting Two Heads Together to Build a Better Brain

Tregs Expand the Skin Stem Cell Niche

Treating Obesity? It's in the Bag!

Volume 26, Issue 2, Pages (February 2018)

Off the Beaten Track: New Neurons in the Adult Human Striatum

The Platypus Genome Unraveled

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Branching Out for Detection of Type 2 Diabetes

Claudio Brunstein, MD, PhD, Keli Hippen, Todd E

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Harnessing regulatory T cells for therapeutic purposes

Adil Mardinoglu, Jan Boren, Ulf Smith Cell Metabolism

Proteins in Plant Brassinosteroid Signaling

Food for Thought: Revisiting the Complexity of Food Intake

Do Cancer Cells Care If Their Host Is Hungry?

The Plasticity of Aging: Insights from Long-Lived Mutants

Volume 13, Issue 4, Pages (April 2011)

MicroRNA-155 Function in B Cells

Comparisons of Diets Used in Animal Models of High-Fat Feeding

Chapter 29 - Stem Cells and Generation of New Cells in the

Regulatory T Cells GATA Have It

An Pan, Xu Lin, Elena Hemler, Frank B. Hu Cell Metabolism

Macrophage Metabolism Shapes Angiogenesis in Tumors

Volume 24, Issue 1, Pages 7-8 (July 2016)

Stem Cells and Oxidants: Too Little of a Bad Thing

Many Roads Lead to the Lipid Droplet

Rejuvenation: It’s in Our Blood

Estrogens and Obesity: Is It All in Our Heads?

Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse

Presentation transcript:

Regulatory T Cell Immunotherapy for Type 1 Diabetes: A Step Closer to Success? Jagadeesh Bayry, Jean-François Gautier Cell Metabolism Volume 23, Issue 2, Pages 231-233 (February 2016) DOI: 10.1016/j.cmet.2016.01.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Scheme of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cell Therapy in Adult Type 1 Diabetes Bluestone et al. (2015) collected 400 ml of blood from patients with recent-onset adult T1D. CD4+CD25+CD127lo regulatory T cells (Tregs) were sorted and expanded for 14 days. Following detailed analysis of expanded Tregs, patients received a single dose of Tregs. During the follow up, patients were assessed for safety and immunological and metabolic parameters. Tracking of adoptively transferred Tregs was also performed. Cell Metabolism 2016 23, 231-233DOI: (10.1016/j.cmet.2016.01.010) Copyright © 2016 Elsevier Inc. Terms and Conditions