The Lack of Associations Between Alleles at the Hypoxia-Inducible Factor 1A C1772T Loci and Responses to Acute Hypoxia Philip J. Hennis, BSc, PhD, Christopher.

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Presentation transcript:

The Lack of Associations Between Alleles at the Hypoxia-Inducible Factor 1A C1772T Loci and Responses to Acute Hypoxia Philip J. Hennis, BSc, PhD, Christopher Bussell, BSc, MSc, PhD, Mark G. Darlison, BSc, MSc, PhD Wilderness & Environmental Medicine Volume 21, Issue 3, Pages 219-228 (September 2010) DOI: 10.1016/j.wem.2010.05.001 Copyright © 2010 Wilderness Medical Society Terms and Conditions

Figure 1 Erythropoietin (EPO) profile according to HIF1A genotype during the 8-hour exposure to 12.7% oxygen. EPO values are represented as a percentage of baseline values; CC (☐), CT/TT (♦). Values are the mean ± 1 SD. aWhole population significantly different from baseline (P <.001). bWhole population significantly different from the 4-hour time point. (P <.001). Wilderness & Environmental Medicine 2010 21, 219-228DOI: (10.1016/j.wem.2010.05.001) Copyright © 2010 Wilderness Medical Society Terms and Conditions

Figure 2 Arterial oxygen saturation (Sao2) profile according to HIF1A genotype during the 8-hour exposure to 12.7% oxygen; CC (☐), CT/TT (♦). Values are the mean ± 1 SD. aWhole population significantly different from baseline at this time point (P <.001). bSao2 at this time point higher than at the 1-hour time point (P = .031). Wilderness & Environmental Medicine 2010 21, 219-228DOI: (10.1016/j.wem.2010.05.001) Copyright © 2010 Wilderness Medical Society Terms and Conditions

Figure 3 Acute mountain sickness (AMS) scores during an 8-hour exposure to 12.7% oxygen according to HIF1A genotype. Values are the mean ± 1 SD. aaWhole population significantly different from baseline at this time point (P <.05). aWhole population significantly different from baseline at this time point (P <.001). Wilderness & Environmental Medicine 2010 21, 219-228DOI: (10.1016/j.wem.2010.05.001) Copyright © 2010 Wilderness Medical Society Terms and Conditions

Figure 4 Example of a 30-minute isocapnic hypoxic ventilatory response (HVR) test showing minute ventilation; V̇E, arterial oxygen saturation; Sao2, and fraction of inspired oxygen; FIo2. Wilderness & Environmental Medicine 2010 21, 219-228DOI: (10.1016/j.wem.2010.05.001) Copyright © 2010 Wilderness Medical Society Terms and Conditions