Volume 184, Issue 4, Pages 1358-1363 (October 2010) Interstitial Cystitis/Painful Bladder Syndrome and Associated Medical Conditions With an Emphasis on Irritable Bowel Syndrome, Fibromyalgia and Chronic Fatigue Syndrome  J. Curtis Nickel, Dean A. Tripp, Michel Pontari, Robert Moldwin, Robert Mayer, Lesley K. Carr, Ragi Doggweiler, Claire C. Yang, Nagendra Mishra, Jorgen Nordling  The Journal of Urology  Volume 184, Issue 4, Pages 1358-1363 (October 2010) DOI: 10.1016/j.juro.2010.06.005 Copyright © 2010 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 1 Patients identified with more associated symptoms had significantly longer symptom duration (years). The Journal of Urology 2010 184, 1358-1363DOI: (10.1016/j.juro.2010.06.005) Copyright © 2010 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 2 Distinct clinical phenotypes (3) of patients with IC/PBS based on identification of overlapping conditions. Phenotypic progression over time may occur in patients originally diagnosed with organ specific IC/PBS to regional and then systemic pain syndromes. For patients originally presenting with other associated condition (IBS, FM and/or CFS) progression trajectory might be bidirectional. Other regional pain syndromes include vulvodynia, pelvic floor spasm/pain, etc. Other systemic pain syndromes include TMD, migraine headaches etc. The Journal of Urology 2010 184, 1358-1363DOI: (10.1016/j.juro.2010.06.005) Copyright © 2010 American Urological Association Education and Research, Inc. Terms and Conditions