The aging kidney Kidney International

Slides:

Advertisements

Similar presentations

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure William C. Wolf, Hideaki.

Advertisements

Volume 65, Issue 1, Pages (January 2004)

Volume 59, Issue 1, Pages (January 2001)

Volume 70, Issue 4, Pages (August 2006)

Volume 63, Issue 6, Pages (June 2003)

Volume 60, Issue 3, Pages (September 2001)

Volume 61, Issue 2, Pages (February 2002)

Volume 56, Issue 6, Pages (December 1999)

Volume 67, Issue 5, Pages (May 2005)

Volume 68, Issue 6, Pages (December 2005)

Volume 61, Issue 2, (February 2002)

IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy J.-A. Moon,

Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2α in interstitial fibroblasts of the renal.

Volume 83, Issue 5, Pages (May 2013)

Volume 65, Issue 1, Pages (January 2004)

Volume 60, Issue 2, Pages (August 2001)

Volume 61, Issue 5, Pages (May 2002)

Adenovirus-mediated kallikrein gene delivery reverses salt-induced renal injury in Dahl salt-sensitive rats Julie Chao, Jenny J. Zhang, Kuei-Fu Lin,

Volume 58, Issue 6, Pages (December 2000)

Volume 66, Issue 6, Pages (December 2004)

Improvement of extraction and processing of RNA from renal biopsies

Volume 67, Issue 3, Pages (March 2005)

Volume 56, Issue 3, Pages (September 1999)

Volume 59, Issue 1, Pages (January 2001)

Hua Liu, Steven A. Bigler, Jeffrey R. Henegar, Radhakrishna Baliga

Volume 59, Issue 3, Pages (March 2001)

Volume 64, Issue 5, Pages (November 2003)

Volume 67, Issue 4, Pages (April 2005)

Effect of advanced glycation end-products on gene expression and synthesis of TNF-α and endothelial nitric oxide synthase by endothelial cells Gloria.

Volume 68, Issue 1, Pages (July 2005)

Hiroyuki Yanagisawa, Nobuyuki Yamazaki, Gen Sato, Osamu Wada

Volume 63, Issue 2, Pages (February 2003)

Gene transfer of truncated IκBα prevents tubulointerstitial injury

Volume 65, Issue 6, Pages (June 2004)

Volume 69, Issue 2, Pages (January 2006)

Volume 55, Issue 2, Pages (February 1999)

Volume 60, Issue 6, Pages (December 2001)

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure William C. Wolf, Hideaki.

Volume 64, Issue 3, Pages (September 2003)

Prevention of mesangial sclerosis by bone marrow transplantation

Abnormal development of glomerular endothelial and mesangial cells in mice with targeted disruption of the lama3 gene C.K. Abrass, A.K. Berfield, M.C.

Volume 65, Issue 2, Pages (February 2004)

Effect of nitric oxide modulation on TGF-β1 and matrix proteins in chronic cyclosporine nephrotoxicity Fuad S. Shihab, Hong Yi, William M. Bennett, Takeshi.

Volume 63, Issue 1, Pages (January 2003)

Volume 67, Issue 2, Pages (February 2005)

Volume 54, Issue 4, Pages (October 1998)

Volume 62, Issue 3, Pages (September 2002)

Hideyuki Murakami, Katsutoshi Yayama, Lee Chao, Julie Chao

Volume 59, Issue 3, Pages (March 2001)

M.-J. Wu, M.-C. Wen, Y.-T. Chiu, Y.-Y. Chiou, K.-H. Shu, M.-J. Tang

Volume 61, Issue 1, Pages (January 2002)

Volume 61, Issue 6, Pages (June 2002)

Volume 68, Issue 5, Pages (November 2005)

Adenovirus-mediated gene transfer to renal glomeruli in rodents

Volume 54, Pages S20-S24 (December 1998)

Volume 56, Issue 1, Pages (July 1999)

Volume 67, Issue 6, Pages (June 2005)

Prasun K. Datta, Elias A. Lianos Kidney International

Zinc deficiency further increases the enhanced expression of endothelin-1 in glomeruli of the obstructed kidney Hiroyuki Yanagisawa, Kazuaki Moridaira,

Volume 62, Issue 2, Pages (August 2002)

Volume 70, Issue 11, Pages (December 2006)

Volume 64, Issue 1, Pages (July 2003)

Volume 65, Issue 2, Pages (February 2004)

Volume 61, Issue 2, Pages (February 2002)

T-PA promotes glomerular plasmin generation and matrix degradation in experimental glomerulonephritis Masashi Haraguchi, Wayne A. Border, Yufeng Huang,

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Richard E. Gilbert, Mark E. Cooper Kidney.

Volume 59, Issue 2, Pages (February 2001)

Volume 65, Issue 6, Pages (June 2004)

Volume 70, Issue 1, Pages (July 2006)

Volume 75, Issue 2, Pages (January 2009)

Presentation transcript:

The aging kidney Kidney International Diego Rodrfguez-Puyol Kidney International Volume 54, Issue 6, Pages 2247-2265 (January 1998) DOI: 10.1038/4499994 Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 1 Schematic representation of the aging process, considering the organism as the sum of Its different cells. Abbreviations are: ROl, reactive oxygen intermediates; AGE, advanced glycosylation end products; mediators, other possible mediators. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 2 Morphologic changes in the renal cortex of 24-month-old Wistar rats. (1) Diffuse glomerular and tubular changes, with cystic appearance and atrophy of the glomerular tuft of some glomeruli, glomerulosclerosis, tubular dilation, and intratuhular casts (PAS X 100). (2) Tubular atrophy, reduplication of basal membranes, and interstitial expansion (PAS X 400). (3) Magnification of a sclerosed glomerulus. near another glomerulas with cystic appearance, in an area with interstitial expansion (PAS x 400). (4) Arteriolar hyalinosis (PAS x 600). Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 3 Expression of the collagen type-IV mRNA (α-i chain) in the renal cortex from 3-month-old (lanes 1 and 2) and 24-month-old (lanes 3 and 4) rats. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 4 Expression of the TGF-β mRNA in the renal cortex from 3-month-old, 18-month-old, 24-month-old, and 30-month-old rats. Upper panel, the simultaneous amphtication of the TGF-pl and GAPDH (housekeeping gene) mRNAs by using RT-PCR, in samples from rats of different ages. Lower panel, the ratio between the two amplification products (TGFf 1/GAPDH) were calculated and the mean SCM of 6 different rats are given. *P < 0.05 versus 3-month-old rats. (Published with permission of JAm Soc Nephrol.) Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 5 Northern blot analysis of the expression of the preproendothelin-1 and GAPDH (housekeeping gene) mRNAs In 3.month-old and 24.month-old rats. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 6 Northern blot analysis of the changes in the preproendothelin-I naRNA expression in cultured bovine aortic endothelial cells Incubated with hydrogen peroxide (100 μM) for different times (4 to 24 hours). Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Fig. 7 Northern blot analysis of the changes in the endothelial coasti. tutive nitric oxide synthase (NOS-3) mRNA expression (upper panel) and in the activity of this enzyme, measured as the conversion of arginiac to citrulline (lower panel), In cultured bovine aortic enclothelial cells incubated with xanthlne (X, 0.1 M) plus xanthlne oxidase (XO, 1 mU/mi) for different times (4 to 24 hours). Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994) Copyright © 1998 International Society of Nephrology Terms and Conditions