Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts Irvin Mayers, MD, Thomas Hurst, MVSc, Lakshmi.

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Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts Irvin Mayers, MD, Thomas Hurst, MVSc, Lakshmi Puttagunta, MD, Anna Radomski, PhD, Taras Mycyk, MD, Grzegorz Sawicki, David Johnson, MD, MPH, Marek W. Radomski, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 122, Issue 4, Pages 746-752 (October 2001) DOI: 10.1067/mtc.2001.116207 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Pro-MMP-9 activity in right atrium (A) and in plasma (B) is increased after bypass. Data are presented as means ± Se. *Significant difference (P <.05) between the paired samples. Insert is a representative patient sample analyzed by means of zymography. Note that the activity of the 72-kd enzyme is indicative of pro-MMP-2, and that of the 92-kd activity is indicative of pro-MMP-9. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 746-752DOI: (10.1067/mtc.2001.116207) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Decrease in TIMP-4 expression in right atrium after bypass. Data are presented as means ± SE. *Siginificant difference (P <.05) between the paired samples. Insert is a representative patient sample analyzed by means of Western blotting. The activity at 29 kd is indicative of TIMP-4. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 746-752DOI: (10.1067/mtc.2001.116207) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Distribution of MMP expression in the right atrium. Staining for MMP-2 expression increases from onset (A) and at termination (B) of CPB in a representative tissue sample. Similarly, staining for MMP-9 expression increases at onset (C) and at termination (D) of CPB. Note that the tissue sections have been magnified at 160×. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 746-752DOI: (10.1067/mtc.2001.116207) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Increased NOS activity in the right atrium. Data are presented as means ± SE. *Significant difference (P <.05) between the paired samples. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 746-752DOI: (10.1067/mtc.2001.116207) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Distribution of NOS activity in the right atrium. There is a slight increase in staining for eNOS expression from onset (A) to termination (B) of CPB. There is a similar slight increase of staining for iNOS expression from onset (C) to termination (D) of CPB. Note that the tissue sections have been magnified at 160×. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 746-752DOI: (10.1067/mtc.2001.116207) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions