A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia by Gerald G. Wulf, Rui-Yu Wang, Ingrid Kuehnle, Douglas Weidner, Frank.

Slides:

Advertisements

Similar presentations

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients by Sarah Mans, Yara Banz,

Advertisements

Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13): December 15, 2008 ©2008 by American Society of Hematology.

Date of download: 6/22/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association of a Leukemic Stem Cell Gene Expression.

Image 1 Detection of minimal residual disease (MRD) in consecutive bone marrow (BM) samples from a patient with relapse (A) and a patient still in remission.

Figure 2 Percentage of CD19+/CD34+ cells with decreased CD81 median fluorescence intensity (MFI;

by Jad I. Belle, David Langlais, Jessica C

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with.

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation.

Hyperdiploid Acute Lymphoblastic Leukemia With 51 to 65 Chromosomes: A Distinct Biological Entity With a Marked Propensity to Undergo Apoptosis by Chikako.

Neoplastic blood cells become pluripotent

The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate-

Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties by Miranda Buitenhuis,

by Benjamin J. Frisch, John M. Ashton, Lianping Xing, Michael W

by Laurence J. N. Cooper, Kevin M. Shannon, Michael R

Reduced Frequency of Regulatory T Cells in Peripheral Blood Stem Cell Compared to Bone Marrow Transplantations Céline Blache, Joe-Marc Chauvin, Aude.

Donor stromal cells from human blood engraft in NOD/SCID mice

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted.

by Udomsak Bunworasate, Hilal Arnouk, Hans Minderman, Kieran L

Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival by Kai-Da Wu, Lisa.

by Venetia Bigley, Laura E. Spence, and Matthew Collin

Gupta V, Tallman MS, Weisdorf DJ

Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)‏

Leukemia initiated by PMLRARα: the PML domain plays a critical role while retinoic acid–mediated transactivation is dispensable by Scott C. Kogan, Suk-hyun.

Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia by Xue-Fei Huang, Shao-Kai Luo,

Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia by Teresa Padró, Sandra Ruiz, Ralf Bieker, Horst Bürger, Martin Steins,

Serum Levels of Substance P Are Elevated in Patients With Sickle Cell Disease and Increase Further During Vaso-Occlusive Crisis by Lisa A. Michaels, Kwaku.

Long-term expansion of effector/memory Vδ2− γδ T cells is a specific blood signature of CMV infection by Vincent Pitard, David Roumanes, Xavier Lafarge,

ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status by Naoyuki Uchida, Brad Dykstra,

Yumi Matsuzaki, Kentaro Kinjo, Richard C Mulligan, Hideyuki Okano

Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase.

CD6 Ligation Modulates the Bcl-2/Bax Ratio and Protects Chronic Lymphocytic Leukemia B Cells From Apoptosis Induced by Anti-IgM by Lyda M. Osorio, Angelina.

Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma by Marion Lambert, Monique.

CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy.

Detection of Trisomy 12 and Rb-Deletion in CD34+ Cells of Patients With B-Cell Chronic Lymphocytic Leukemia by B. Gahn, C. Schäfer, J. Neef, C. Troff,

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia by Donya Moradi Manesh, Jad El-Hoss, Kathryn.

Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia by Anna Rogers, Youngson.

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate by E.L.

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association.

Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma by Jumpei Yamazaki, Takuo Mizukami, Kazuya.

by Hyung-Gyoon Kim, Kyoko Kojima, C. Scott Swindle, Claudiu V

by Giridharan Ramsingh, Meagan A. Jacoby, Jin Shao, Rigoberto E

by Hiroyuki Kawagoe, and Gerard C. Grosveld

by David Grimwade, and Sylvie D. Freeman

A Strong Expression of CD44-6v Correlates With Shorter Survival of Patients With Acute Myeloid Leukemia by S. Legras, U. Günthert, R. Stauder, F. Curt,

Loss of Heterozygosity and Microsatellite Instability at theMLL Locus Are Common in Childhood Acute Leukemia, but not in Infant Acute Leukemia by Julie.

Complete remission through blast cell differentiation inPLZF/RARα-positive acute promyelocytic leukemia: in vitro and in vivo studies by Maria C. Petti,

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells by Bing Z. Carter, Marcela Gronda,

Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia by Heidi J. Nick, Hyung-Gyoon.

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant.

Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development by Armelle Le Campion, Marie-Claude Gagnerault, Cédric.

Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia by Floriana Manodoro, Jacek Marzec, Tracy.

Donor Cell Leukemia in Umbilical Cord Blood Transplant Patients

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy by Sara Mastaglio, Eric Wong, Travis.

by Silvia Mele, Stephen Devereux, Andrea G

Volume 24, Issue 9, Pages (September 2016)

VAY-736 combines effectively with ibrutinib in vivo.

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

Volume 16, Issue 5, Pages (May 2002)

A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease John A. Hansen, Samir M. Hanash, Laura Tabellini, Chris Baik, Richard L.

by Geling Li, Emily Waite, and Julie Wolfson

David Traver, Koichi Akashi, Irving L. Weissman, Eric Lagasse Immunity

A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia by Lili Aslostovar, Allison L. Boyd, Mohammed.

Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia by Ross Kinstrie, Dimitris Karamitros, Nicolas Goardon, Heather Morrison,

HOXB6 overexpression results in delayed AML

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

Adipocytes sequester daunorubicin (DNR).

Volume 21, Issue 4, Pages (April 2013)

Leukemic blasts express a “hypoxia signature

Mary Eapen Biology of Blood and Marrow Transplantation

Presentation transcript:

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia by Gerald G. Wulf, Rui-Yu Wang, Ingrid Kuehnle, Douglas Weidner, Frank Marini, Malcolm K. Brenner, Michael Andreeff, and Margaret A. Goodell Blood Volume 98(4):1166-1173 August 15, 2001 ©2001 by American Society of Hematology

Characteristic Hoechst 33342 staining profiles of MNC fractions from patients with AML.SP cells (1.29% of MNCs, as boxed) were found in the bone marrow (panel A) but not the peripheral blood (panel B) of an AML patient with more than 90% blasts in both tiss... Characteristic Hoechst 33342 staining profiles of MNC fractions from patients with AML.SP cells (1.29% of MNCs, as boxed) were found in the bone marrow (panel A) but not the peripheral blood (panel B) of an AML patient with more than 90% blasts in both tissues. Gerald G. Wulf et al. Blood 2001;98:1166-1173 ©2001 by American Society of Hematology

Prevalence of SP cells in bone marrow and peripheral blood specimens of patients with AML.The results are reported as percentages of viable MNCs per sample and were grouped according to the patients' disease stage (untreated, in complete hematological remis... Prevalence of SP cells in bone marrow and peripheral blood specimens of patients with AML.The results are reported as percentages of viable MNCs per sample and were grouped according to the patients' disease stage (untreated, in complete hematological remission, or relapsed/resistant). Horizontal bars indicate median values. Gerald G. Wulf et al. Blood 2001;98:1166-1173 ©2001 by American Society of Hematology

Heterogeneous expression of CD34 and CD38 on the SP cells of patients with AML.The patient samples were grouped into active disease (untreated and relapsed/resistant) or complete hematological remission. Heterogeneous expression of CD34 and CD38 on the SP cells of patients with AML.The patient samples were grouped into active disease (untreated and relapsed/resistant) or complete hematological remission. Median values are indicated by horizontal bars. Gerald G. Wulf et al. Blood 2001;98:1166-1173 ©2001 by American Society of Hematology

Efflux of daunorubicin and mitoxantrone from leukemic SP cells in bone marrow samples from 3 patients with AML.After incubation of the cells with Hoechst 33342 and daunorubicin (panels A, C, E) or mitoxantrone (panels B, D, F), the fluorescence emitted by t... Efflux of daunorubicin and mitoxantrone from leukemic SP cells in bone marrow samples from 3 patients with AML.After incubation of the cells with Hoechst 33342 and daunorubicin (panels A, C, E) or mitoxantrone (panels B, D, F), the fluorescence emitted by the drugs was plotted for 3 gated cell populations: SP (solid line, shaded); non-SP (dashed line); and negative control, SP cells stained with Hoechst 33342 alone (dotted line). Gerald G. Wulf et al. Blood 2001;98:1166-1173 ©2001 by American Society of Hematology

Generation of AML-like disease by human CD34low/− SP cells in the NOD/SCID mouse.Leukemic blasts staining positively for human CD45 were found infiltrating the murine host spleen (panel A, 60 ×) and the bone marrow (panel B, 100 ×). Generation of AML-like disease by human CD34low/− SP cells in the NOD/SCID mouse.Leukemic blasts staining positively for human CD45 were found infiltrating the murine host spleen (panel A, 60 ×) and the bone marrow (panel B, 100 ×). FISH with a centromeric probe for chromosome 7 (D7Z1) showed monosomic blasts infiltrating the bone marrow of this mouse (panel C, 100 ×). Gerald G. Wulf et al. Blood 2001;98:1166-1173 ©2001 by American Society of Hematology