The repeat domain of Tau cross-links to α-tubulin.

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The repeat domain of Tau cross-links to α-tubulin. The repeat domain of Tau cross-links to α-tubulin. (A) Separation of cross-linked Tau-tubulin complexes by SDS/PAGE. (B) Map of cross-linked lysine residues. Cross-links are marked by dashed lines. Only cross-links from Tau to Lys336 and Lys338 in α-tubulin were observed. (C) Three-dimensional structure of the (Tc)2R complex (PDB ID code 1Z2B; ref. 31). Vinblastine is shown as red sphere model. Lys336 and Lys338 are highlighted in blue. Harindranath Kadavath et al. PNAS 2015;112:24:7501-7506 ©2015 by National Academy of Sciences