Nat. Rev. Rheumatol. doi: /nrrheum

Slides:

Advertisements

Similar presentations

Hematopoiesis from pluripotent stem cells to mature, differentiated, cellular effectors of immunity and more Richard A. Poirier for HHMI/Harvard Immunology.

Advertisements

Images  Wikimedia Hematopoietic stem cells Hematopoietic progenitor cells Common lymphoid progenitorCommon myeloid progenitor In ThymusIn Bone marrow.

M1 – Immunology CYTOKINES AND CHEMOKINES March 26, 2009 Ronald B

Research, 2016, Vol. 4, No. 1, doi: /jfnr-4-1-6

Nat. Rev. Rheumatol. doi: /nrrheum

Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1 by Haejung Won, Vijayalakshmi Nandakumar,

Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 5 Involvement of B cells in SLE

Myeloid Lineage Commitment from the Hematopoietic Stem Cell

When IFN interferes with cell fate

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Induction of immune tolerance

Figure 4 Simplified T cell and antigen presenting

Figure 3 Proposed mechanisms underlying the links

Figure 1 Four nodes to target when inducing anti-tumour immunity

Essentials of Th17 cell commitment and plasticity

Figure 5 Defects in the JAK–STAT signalling pathway

Figure 1 Immune mechanisms in liver homeostasis

Cells and organs of Immune system

Figure 3 Nucleic acid sensors in SLE

Figure 3 TNFSF activities enhancing immune cell activation

Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Figure 2 Molecular pathways involved in the regulation of T-cell differentiation and cytokine production Figure 2 | Molecular pathways involved in the.

Nat. Rev. Rheumatol. doi: /nrrheum

Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Overview of the immunopathogenesis of ulcerative colitis

Figure 2 Microbiota and osteoimmunology

Figure 6 Lack of IRF5 causes a reduction in neutrophil influx

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

Figure 3 Differentiation and functional control of T-cell subsets

Figure 4 Macrophages in liver inflammation

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Effect of sialylated glycoforms on IgG activity

Nat. Rev. Rheumatol. doi: /nrrheum

A Lasting Impression: Epigenetic Memory of Bacterial Infections?

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Inflammatory mechanisms in tendinopathy

Development of Dendritic-Cell Lineages

Decoding Chromatin Goes High Tech

CELLS INVOLVES IN IMMUNITY UTTARAN MODHUKALYA 1. CONTENT 1. INTRODUCTION 2. HEMATOPOIETIC STEM CELL 3. LYMPHOCYTE CELL 4. MYELOID CELL 5. REFERENCE 6.

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Mucosal immune networks

Figure 2 GM-CSF — a key player in inflammation and autoimmunity

Nat. Rev. Rheumatol. doi: /nrrheum

Long Noncoding RNA in Hematopoiesis and Immunity

Figure 2 Embryonic origins of tissue-resident macrophages

Thymus Exclusivity: All the Right Conditions for T Cells

We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers

Figure 4 Bile-acid-induced TGR5 signalling pathways in macrophages

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Underlying mechanisms of TREG cells in atherosclerosis

Nat. Rev. Rheumatol. doi: /nrrheum

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

Figure 1 The role of macrophages in RA

Mechanisms of virus-induced airway inflammation in chronic obstructive pulmonary disease (COPD). Mechanisms of virus-induced airway inflammation in chronic.

Figure 1 Monocyte and macrophage ontogeny

GATA-3 Function in Innate and Adaptive Immunity

The Transcriptional Regulation of B Cell Lineage Commitment

Figure 5 TLR-dependent signaling pathways inhibited by glatiramer acetate Myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-1 receptor.

Volume 13, Issue 4, Pages (April 2008)

Marking Emerging β- and γδ-Selected T Cells

Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung. a) Metacore analyses of pathway enrichment in IPF versus control.

Toll-like receptors, adapter proteins, and signaling molecules.

Volume 26, Issue 6, Pages (June 2007)

Development and function of MDSCs

Presentation transcript:

Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.91 Figure 4 PU.1 in the transcriptional control of macrophage development and activation Figure 4 | PU.1 in the transcriptional control of macrophage development and activation. a | Runt-related transcription factor 1 (RUNX1) is required during early development in haematopoietic stem cells (HSCs), and is followed by the onset of PU.1 expression. PU.1 is the master regulator of the myeloid lineage and is crucial throughout differentiation. Interferon regulatory factor (IRF) 8, early growth response protein (EGR) 1 and EGR2 are involved in suppressing granulocyte and neutrophil genes while promoting macrophage fate. Krueppel-like factor 4 (KLF4) is required for monocyte to macrophage differentiation. During inflammation, macrophages are shaped by the cytokine environment, which depends on the nature of the infectious insult. Bacterial pathogens cause a type 1 T helper cell (TH1) or TH17 response, which leads to activation of signal transducer and activator of transcription (STAT) 1 and IRF5, leading to a classically activated M1 phenotype. Parasites lead to a type 2 T helper cell (TH2) response that activates STAT6 and IRF4 in macrophages, resulting in an alternatively activated M2 phenotype. In vivo, multiple macrophage phenotypes exist along a continuum with M1 and M2 at the extremes. b | Typical composition of PU.1-marked enhancers and promoters in classically activated M1 macrophages. Binding of STAT1 is associated with latent, but not constitutive or poised enhancers82. The chromatin modification histone H3 lysine 4 monomethylation (H3K4me1) is associated with active enhancer elements, whereas histone H3 lysine 4 trimethylation (H3K4me3) is associated with active promoters. CMoP, common monocyte progenitor; CMP, common myeloid progenitor; DC, dendritic cell; GMP, granulocyte–macrophage progenitor; Ly6C, lymphocyte antigen 6C2; MDP, monocyte and dendritic cell progenitor; NF-κB, nuclear factor κB. Udalova, I. A. et al. (2016) Macrophage heterogeneity in the context of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.91