Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure Eline L. Vegter, Daniela Schmitter, Yanick.

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Presentation transcript:

Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure Eline L. Vegter, Daniela Schmitter, Yanick Hagemeijer, Ekaterina S. Ovchinnikova, Pim van der Harst, John R. Teerlink, Christopher M. O'Connor, Marco Metra, Beth A. Davison, Daniel Bloomfield, Gad Cotter, John G. Cleland, Michael M. Givertz, Piotr Ponikowski, Dirk J. van Veldhuisen, Peter van der Meer, Eugene Berezikov, Adriaan A. Voors, Mohsin A.F. Khan International Journal of Cardiology Volume 224, Pages 231-239 (December 2016) DOI: 10.1016/j.ijcard.2016.09.010 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Patient grouping according to PROTECT primary endpoint definitions. Patients (n=100) were divided in 4 groups based on the trichotomous endpoint of the PROTECT study; Treatment Failure, Unchanged (=no change) or Success (=improving). The patients in the Failure group were further divided in failure-worsening and failure-intermediate based on additional clinical criteria for the failure-worsening group. International Journal of Cardiology 2016 224, 231-239DOI: (10.1016/j.ijcard.2016.09.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Correlation heatmaps. Heatmaps for the 4 clinical groups at 48h of hospitalization. Red indicates a negative correlation, green a positive correlation. Increasing intensity of the color corresponds to a stronger correlation, the numbers in the heatmap represent the Rho values. The significant correlations after correction are outlined in bold. A. Correlation heatmap of the improving group. B. Correlation heatmap of the no change group. C. Correlation heatmap of the failure-intermediate group. D. Correlation heatmap of the failure-worsening group. CRP indicates C-reactive protein; TNFR-1, tumor necrosis factor alpha receptor 1; WAP-4C, WAP four-disulfide core domain protein HE4; sST-2, soluble ST-2; GDF-15, growth differentiation factor 15; BUN, blood urea nitrogen; proADM, pro-adrenomedullin and VEGFR-1, vascular endothelial growth factor receptor 1. International Journal of Cardiology 2016 224, 231-239DOI: (10.1016/j.ijcard.2016.09.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 Pathway analysis heatmap. Significant pathways predicted by DIANA-miRPath (v.2.0) are depicted on the X-axis and miRNAs on the Y-axis. The color code represents the log(p-value), with the most significant predicted miRNA-pathway interactions in red. International Journal of Cardiology 2016 224, 231-239DOI: (10.1016/j.ijcard.2016.09.010) Copyright © 2016 The Authors Terms and Conditions