Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma Patrick Booms, MSca, David.

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Presentation transcript:

Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma Patrick Booms, MSca, David Cheung, MDa, Mieke C. Timmers, a, Aeilko H. Zwinderman, PhD b, Peter J. Sterk, PhDa Journal of Allergy and Clinical Immunology Volume 99, Issue 3, Pages 330-334 (March 1997) DOI: 10.1016/S0091-6749(97)70050-2 Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Average dose-response curves to inhaled methacholine in the placebo-treated group (left) and in the budesonide-treated group (right) at week 0 (entry, continuous lines ) and week 12 (end of treatment period, dotted lines). Data points have been included if more than 50% of patients inhaled the plotted methacholine dose. Journal of Allergy and Clinical Immunology 1997 99, 330-334DOI: (10.1016/S0091-6749(97)70050-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 Percentage of patients exhibiting a maximal-response plateau on the dose-response curve of FEV1 to inhaled methacholine in placebo and budesonide groups during run-in, treatment, and washout periods. Journal of Allergy and Clinical Immunology 1997 99, 330-334DOI: (10.1016/S0091-6749(97)70050-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Geometric mean values (±SEM in 2log values; doubling doses) of PC20 before, during, and after treatment with placebo (open symbols) or inhaled budesonide (closed symbols). Journal of Allergy and Clinical Immunology 1997 99, 330-334DOI: (10.1016/S0091-6749(97)70050-2) Copyright © 1997 Mosby, Inc. Terms and Conditions