Improving Risk Assessment and Early Diagnosis in PAH

Program Themes

Initial Presentation

Initial Presentation (cont)

Physical Exam

Physical Exam (cont)

Physical Exam (cont)

Evaluation of Findings

Test Results: Echo (May 2015)

What Else Can Be Learned From Echo?

Additional Diagnostics

RHC Results

Determinants of Prognosis in PAH

Therapies Based on Risk

Initial Therapy

Clinical Efficacy/Safety AMBITION Trial

Evolving Approach to Combination Therapy

Follow-Up Visit (September 2015)

Echo (March 2016)

RHC Results: Hemodynamics

Clinical Follow-Up + Objective Evaluation

5th World Symposium on PH Goals of Therapy: Setting the Bar Higher

Clinical Efficacy/Safety GRIPHON Trial

GRIPHON: Treatment Effect by Subgroup

Conclusions

Abbreviations

Abbreviations (cont)

Abbreviations (cont)