Volume 55, Issue 6, Pages 1386-1396 (June 2009) Bladder Tumor Infiltrating Mature Dendritic Cells and Macrophages as Predictors of Response to Bacillus Calmette-Guérin Immunotherapy  Cherifa Ayari, Hélène LaRue, Hélène Hovington, Marc Decobert, François Harel, Alain Bergeron, Bernard Têtu, Louis Lacombe, Yves Fradet  European Urology  Volume 55, Issue 6, Pages 1386-1396 (June 2009) DOI: 10.1016/j.eururo.2009.01.040 Copyright © 2009 European Association of Urology Terms and Conditions

Fig. 1 (a–d) Immunohistochemistry (IHC) detection of mature CD83+ dendritic cells on bladder tumor sections; note infiltration in lymphoid aggregate (a and c), in the papillary axis (b), and in the underlying stroma (d). (e–h) IHC detection of expression of CD68 on bladder tumor sections: note infiltration in the stroma (e and h), in a lymphoid aggregate (f), and in the tumor (e, g, and h), and expression of CD68 by tumor cells (e and g). Microscopic field: ×10, except for d and g at ×20. European Urology 2009 55, 1386-1396DOI: (10.1016/j.eururo.2009.01.040) Copyright © 2009 European Association of Urology Terms and Conditions

Fig. 2 Kaplan-Meier analysis of recurrence-free survival according to the number of cycles of maintenance bacillus Calmette-Guérin (BCG; no or one cycle compared with more than one cycle) for patients presenting (a) a low score or (b) a high score of tumor infiltration by CD83+ dendritic cells. European Urology 2009 55, 1386-1396DOI: (10.1016/j.eururo.2009.01.040) Copyright © 2009 European Association of Urology Terms and Conditions

Fig. 3 Kaplan-Meier analysis of recurrence-free survival according to (a) the level of tumor infiltration by CD68+ macrophages, (b) the expression of CD68 in tumor cells, or (c) the combination of both. European Urology 2009 55, 1386-1396DOI: (10.1016/j.eururo.2009.01.040) Copyright © 2009 European Association of Urology Terms and Conditions