Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients

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Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients Hong Pan, M.D., Jian-Zhong Sheng, Ph.D., Li Tang, M.D., Rong Zhu, M.D., Tian-Hua Zhou, Ph.D., He-Feng Huang, M.D. Fertility and Sterility Volume 90, Issue 4, Pages 1000-1007 (October 2008) DOI: 10.1016/j.fertnstert.2007.07.1386 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Immunostaining of c-fos protein in different groups of endometria. A, Normal eutopic endometrium; B, eutopic endometrium from endometriotic patients; C, ectopic endometrium from endometriotic patients; and D, negative control. Original magnification: ×400. (B) H-SCORE of c-fos protein staining in different groups of endometria. ∗P<.05, compared with normal eutopic endometria. Fertility and Sterility 2008 90, 1000-1007DOI: (10.1016/j.fertnstert.2007.07.1386) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Western blotting analysis of c-fos and MMP-9 protein expression in different groups of endometria throughout the menstrual cycle. (A, C) Expression of c-fos and MMP-9 proteins in endometria from the patients with or without endometriosis, respectively. A, Eutopic endometrium at the proliferative phase from the endometriotic patients; B, ectopic endometrium at the proliferative phase; C, eutopic endometrium at the proliferative phase from the controls; D, eutopic endometrium at the secretory phase from the endometriotic patients; E, ectopic endometrium at the secretory phase; F, eutopic endometrium at the secretory phase from the controls. (B, D) Summary data of c-fos and MMP-9 protein expression, respectively. Euto, eutopic endometria from the endometriotic patients; Ecto, ectopic endometria; Endo, eutopic endometria from the controls. ∗P<.05, compared with normal eutopic endometria at the same menstrual phase. #P<.05, ##P<.01, compared with the corresponding secretory endometria, respectively. Fertility and Sterility 2008 90, 1000-1007DOI: (10.1016/j.fertnstert.2007.07.1386) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 (A) Correlation between c-fos protein levels and MMP-9 protein levels in all the 80 endometrial tissues examined (P<.01, r = .511); (B) Correlation between c-fos protein levels in eutopic endometria and 17β-E2 concentrations in sera of the endometriotic patients at the proliferative phase (P<.01, r = .855); (C) Correlation between c-fos protein levels in eutopic endometria and 17β-E2 concentrations in sera of the controls at the proliferative phase (P<.05, r = .614). Fertility and Sterility 2008 90, 1000-1007DOI: (10.1016/j.fertnstert.2007.07.1386) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions