The Ids Have It Cancer Cell

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Presentation transcript:

The Ids Have It Cancer Cell Lincoln A. Edwards, Howard A. Fine Cancer Cell Volume 18, Issue 6, Pages 543-545 (December 2010) DOI: 10.1016/j.ccr.2010.11.028 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 The Cellular Response to TGF-β Activity Depends, in Part, on Id1 Activation or Repression (A) TGF-β binding to type I (TβRI) and type II (TβRII) receptors leads to Smad activation and Smad binding to TGF-β-responsive elements located at the Id1 promoter. The resulting cellular response (e.g., self-renewal, differentiation) is cell context dependent. (B) In epithelial cells, the availability of the TNF-α associated transcriptional co-repressor, ATF3, in conjunction with the Smad complex results in transcription repression of Id1. (C) In many, but not all, glioma initiating cells (GICs), ATF3 is not produced, leading to Smad-mediated Id1 transcriptional activation. Cancer Cell 2010 18, 543-545DOI: (10.1016/j.ccr.2010.11.028) Copyright © 2010 Elsevier Inc. Terms and Conditions