Vaccine Adjuvants: Putting Innate Immunity to Work

Slides:



Advertisements
Similar presentations
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Advertisements

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,
Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
Suzanne L. Topalian, Charles G. Drake, Drew M. Pardoll  Cancer Cell 
The beauty of TLR agonists for CTCL
Cytosolic DNA Sensing: The Field Narrows
Antigen-Primed CD8+ T Cells Call DCs for Back Up
CD5: A New Partner for IL-6
Bridget A. Robinson, Timothy J. Nice  Immunity 
Gut Microbiota: A Natural Adjuvant for Vaccination
From Oncogene Interference to Neutrophil Immune Modulation
How Many Subsets of Innate Lymphoid Cells Do We Need?
CD8+ T Cell Differentiation: Choosing a Path through T-bet
Toll-like Receptors Keep Antigen Sorting on the Right Track
Eos, Goddess of Treg Cell Reprogramming
The Birds, the Bees, and Innate Immunity
Microbial Learning Lessons: SFB Educate the Immune System
2008: A MyD88 O, DC  Bali Pulendran, Weiping Cao  Immunity 
Toll-like Receptor 9, What O'Clock Is It?
Some DCs Are “B”etter Immunity
Treg's Alter Ego: An Accessory in Tumor Killing
Malaria Vaccine Design: Immunological Considerations
Nicholas van Bruggen, Wenjun Ouyang  Immunity 
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Understanding Immunosuppression after Sepsis
A Flt3L Encounter: mTOR Signaling in Dendritic Cells
T Helper 17 Cells Get the NOD
Understanding Immunosuppression after Sepsis
CD4 Helpers Put Tissue-Resident Memory Cells in Their Place
Dendritic Cells Break Bonds to Tolerize
Mitchell Kronenberg, Yuki Kinjo  Immunity 
Intracellular Pathogens and CD8+ Dendritic Cells: Dangerous Liaisons
Shannon M. Kahan, Allan J. Zajac  Immunity 
Interleukin-17 Kick-Starts T Helper 1 Cell Differentiation
Volume 26, Issue 3, Pages (March 2007)
Development of Dendritic-Cell Lineages
Stuart M. Levitz, Douglas T. Golenbock  Cell 
BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens
Etiology of Type 1 Diabetes
Innate Immunity: Ignored for Decades, but Not Forgotten
Adam C. Silver, Alvaro Arjona, Wendy E. Walker, Erol Fikrig  Immunity 
An IL-1β-Dependent Switch in Innate Mucosal Immunity?
Turning Tumors into Vaccines: Co-opting the Innate Immune System
In Vivo Role of pDCs in Regulating Adaptive Immunity
Immunology of Food Allergy
Stuart M. Levitz, Douglas T. Golenbock  Cell 
I Remember You: Epigenetic Priming in Epithelial Stem Cells
Immune responses induced by TLR TLR7/8 ligands in primary human DC subsets. Immune responses induced by TLR TLR7/8 ligands in primary human DC subsets.
Innate Lymphoid Cells in Inflammation and Immunity
Natural “Helper” Cells in the Lung: Good or Bad Help?
From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells
Wenjun Ouyang, Anne O’Garra  Immunity 
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
TLR2 Looks at Lipoproteins
Volume 26, Issue 4, Pages (April 2007)
IL-1 Can Act as Number One
DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde
Volume 30, Issue 2, Pages (February 2009)
Professional Differences in Antigen Presentation to iNKT Cells
Regulatory B Cells: Origin, Phenotype, and Function
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Trained Immunity: A Memory for Innate Host Defense
Regulatory T Cells in Asthma
The Biology of Intestinal Immunoglobulin A Responses
Taking a Toll Road to Better Vaccines
Some DCs Are “B”etter Immunity
CD14: Chaperone or Matchmaker?
Volume 27, Issue 5, Pages (November 2007)
IL-9 by INFERence Immunity
Presentation transcript:

Vaccine Adjuvants: Putting Innate Immunity to Work Robert L. Coffman, Alan Sher, Robert A. Seder  Immunity  Volume 33, Issue 4, Pages 492-503 (October 2010) DOI: 10.1016/j.immuni.2010.10.002 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 PRR Ligands Shape Adaptive T Cell Immunity through Direct and Indirect Effects on Dendritic Cells (A) Expression of PRRs in human antigen-presenting and nonhematopoietic cells. The ability of the corresponding PRR ligands to produce cytokines and induce Th1 cell and cross-presentation from such cells is depicted below. MPL-based adjuvants (ASO1, ASO2, ASO4) activate monocyte and myeloid DCs, whereas TLR7 (Imiquimod) and TLR9 (CpG) ligands activate pDCs. Such adjuvants induce Th1 cell and low-level CD8+ T cell responses. In humans, it is not clear whether these cells contribute to cross-priming in vivo. (B) The influence of direct innate activation and antigen presentation, bystander innate immunity on antigen presentation, or both together are shown. The relative potency of Th1 cell and CD8+ T cell immunity from these respective pathways are derived from in vivo mouse studies. Optimal Th1 cell and CD8+ T cell immunity is elicited by direct activation of antigen-presenting cells and bystander production of type I IFN. This can be achieved by using Poly IC and TLR7-TLR8 ligands as adjuvants, with the source of type I IFN derived from nonhematopoetic and pDCs, respectively. Immunity 2010 33, 492-503DOI: (10.1016/j.immuni.2010.10.002) Copyright © 2010 Elsevier Inc. Terms and Conditions