Outcome analysis in Crohn’s disease using endomicroscopy: How important and reliable is in vivo analysis of microscopic changes? Ralf Kiesslich, MD,

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Outcome analysis in Crohn’s disease using endomicroscopy: How important and reliable is in vivo analysis of microscopic changes? Ralf Kiesslich, MD, PhD Gastrointestinal Endoscopy Volume 87, Issue 6, Pages 1515-1517 (June 2018) DOI: 10.1016/j.gie.2018.02.038 Copyright © 2018 Terms and Conditions

Figure 1 Endomicroscopic views of impaired intestinal barrier function. A, Normal colonic crypt architecture: lumen of colonic crypts remains dark (arrow). B, Fluorescein leakage within colonic crypts (arrow) and visible irregular crypt architecture. C, Normal villi architecture in the terminal ileum. Single villi with vessels and epithelial border can be readily seen. The lumen remains dark (arrow). D, Fluorescein leakage due to higher permeability of the epithelial cell layer. The lumen becomes bright (arrow). Gastrointestinal Endoscopy 2018 87, 1515-1517DOI: (10.1016/j.gie.2018.02.038) Copyright © 2018 Terms and Conditions