Change in mean serum creatinine, PAC-guided vs empiric therapy

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Change in mean serum creatinine, PAC-guided vs empiric therapy Time frame Clinically guided therapy PAC-guided therapy p From baseline to discharge (mg/dL) +0.14 -0.01 0.02 From baseline to hospital day 7 (mg/dL) +0.11 +0.02 0.01 PAC=pulmonary-artery catheter Nohria A et al. Heart Failure Society of America 2005 Annual Scientific Meeting; September 18-21, 2005; Boca Raton, FL.

Drug use, PAC-guided vs empiric therapy Drug class Clinically guided therapy (%) PAC-guided therapy (%) p Vasodilators, in-hospital (%) 20 39 <0.0001 Thiazide diuretics, in-hospital (%) 34 24 0.02 Loop diuretics, in-hospital (%) 99 NS Loop diuretics, mean discharge dosage levels (mg/d) 180 138 0.01 PAC=pulmonary-artery catheter Nohria A et al. Heart Failure Society of America 2005 Annual Scientific Meeting; September 18-21, 2005; Boca Raton, FL.