Volume 119, Issue 3, Pages (September 2000)

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Volume 119, Issue 3, Pages 774-781 (September 2000) Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis Laurent Spahr, François Vingerhoets, François Lazeyras, Jacqueline Delavelle, Renaud DuPasquier, Emile Giostra, Gilles Mentha, François Terrier, Antoine Hadengue Gastroenterology Volume 119, Issue 3, Pages 774-781 (September 2000) DOI: 10.1053/gast.2000.17857 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 MRI scan of a (A) healthy subject and (B) typical patient with cirrhosis showing pallidal hyperintensity. The BG and occipital WM voxels of interest used for MRS studies are framed in A. Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 T1-weighted MRI intensity (expressed as signal-to-noise ratio) of the different brain regions in patients with cirrhosis and mild HE (▩; n = 9), no HE (▨; n = 10), or in healthy subjects (□; n = 6). Values are presented as median and interquartile range. *P < 0.01 and **P < 0.05 vs. healthy subjects. Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Spectra obtained at MRS in BG and occipital WM from a (A) typical patient with cirrhosis and (B) healthy subject. Arrows indicate abnormal metabolite ratios (Ino/Cr and Cho/Cr) in patients with cirrhosis. Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Metabolite ratios obtained at MRS in (A) BG and (B) occipital WM in patients with cirrhosis and mild HE (▩; n = 9), no HE (▨; n = 10), or in healthy subjects (□; n = 6). Values are presented as median and interquartile range. *P < 0.02 vs. healthy subjects. Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 5 Correlation between UPDRS score and pallidal intensity (expressed as signal-to-noise ratio) in patients with cirrhosis (n = 18). Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 6 Correlation between UPDRS score and Cho/Cr ratio in the BG in patients with cirrhosis (n = 18). Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 7 Correlation between Purdue Pegboard score and Cho/Cr ratio in the BG in patients with cirrhosis (n = 18). Gastroenterology 2000 119, 774-781DOI: (10.1053/gast.2000.17857) Copyright © 2000 American Gastroenterological Association Terms and Conditions