S.M. Nelson, A. La Marca Reproductive BioMedicine Online

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Presentation transcript:

The journey from the old to the new AMH assay: how to avoid getting lost in the values S.M. Nelson, A. La Marca Reproductive BioMedicine Online Volume 23, Issue 4, Pages 411-420 (October 2011) DOI: 10.1016/j.rbmo.2011.06.011 Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Passing and Bablok regression analysis between anti-Müllerian hormone (AMH) concentrations (ng/ml) obtained with Immunotech AMH and AMH Gen II ELISA assays for 120 serum samples. Linear regression analysis results were r=0.99; P<0.0001; y=1.0x. Reproduced with permission from Kumar et al. (2010). Reproductive BioMedicine Online 2011 23, 411-420DOI: (10.1016/j.rbmo.2011.06.011) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Multicentric evaluation of Diagnostic Systems Lab (DSL) anti-Müllerian hormone (AMH) assay and Beckman Coulter AMH Generation II (GenII) assay, for 271 samples across the assay range. Top panel=Passing and Bablok regression (intercept 0.62, 95% CI −1.51–0.28, SE 0.46; slope 1.39, 95% CI 1.35–1.44, SE 0.020). Bottom panel=Bland Altman plot (solid line=mean difference; dotted lines=95% CI). Reproduced with permission from Wallace et al. (2011). CI=Confidence interval; SE=standard error. Reproductive BioMedicine Online 2011 23, 411-420DOI: (10.1016/j.rbmo.2011.06.011) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Anti-Müllerian hormone (AMH) nomogram for values obtained by the Diagnostic Systems Lab assay, based on a quadratic model of log(AMH) on age, showing predicted AMH value versus age and reference centiles of the distribution. Reproduced with permission from Nelson et al. (2011b). Reproductive BioMedicine Online 2011 23, 411-420DOI: (10.1016/j.rbmo.2011.06.011) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions