High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press.

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High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 1. Experimental set-up using high resolution ultrasonography (HRU) for the analysis of kidney and cyst volumes in anaesthetized PCK rats. © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 2. Representative transverse 2-dimensional (2-D) B-mode images of the right kidney, overlaid with power Doppler (red areas) to identify blood flow within the renal parenchyma in 7-week old PCK rat (A), 12-week old PCK rat (B), 10-week old Cy/+ (Han:SPRD) rat (C) and 12-week old wild-type (+/+) rat (the latter is a 2-D B-mode image without power Doppler) (D). © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 3. Correlation of stereological total kidney volume (TKVs) with automated total kidney volume (TKVa) (A and B) and with ellipsoid total kidney volume (TKVe) (C and D) in 7- and 12-week old PCK rats (n=18). © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 4. Correlation of total kidney weight (TKW) with stereological total kidney volume (TKVs) (A) and with automated total kidney volume (TKVa) (B) in 7- and 12-week old PCK rats (n=18). © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 5. Detection of cysts in male PCK rats by histology using Periodic acid-Schiff (PAS) staining in 7-week old (A) and 12-week old (B) PCK rats. Correlation of areal cystic index (%) obtained from histological analysis (HA) with volumetric cystic index (%) obtained from high resolution ultrasonography (HRU) using stereological method (HRUs) in PCK rats (C) (n=18). © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease Kidney Blood Press Res 2016;41:186-196 - DOI:10.1159/000443420 Fig. 6. A 3-dimensional (3-D) reconstruction from a PCK rat kidney showing the tracings of the outer cyst wall used for the final reconstruction (A), allowing visualisation of the kidney and the intra-parenchymal cysts and their spatial orientation (B). © 2016 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0